Wnt signalling in neuronal differentiation and development

Nibaldo C. Inestrosa, Lorena Varela-Nallar

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

121 Citas (Scopus)

Resumen

Wnts are secreted glycoproteins that play multiple roles in early development, including the differentiation of precursor cells. During this period, gradients of Wnts and other morphogens are formed and regulate the differentiation and migration of neural progenitor cells. Afterwards, Wnt signalling cascades participate in the formation of neuronal circuits, playing roles in dendrite and axon development, dendritic spine formation and synaptogenesis. Finally, in the adult brain, Wnts control hippocampal plasticity, regulating synaptic transmission and neurogenesis. In this review, we summarize the reported roles of Wnt signalling cascades in these processes with a particular emphasis on the role of Wnts in neuronal differentiation and development.

Idioma originalInglés
Páginas (desde-hasta)215-223
Número de páginas9
PublicaciónCell and Tissue Research
Volumen359
N.º1
DOI
EstadoPublicada - ene. 2015

Áreas temáticas de ASJC Scopus

  • Patología y medicina forense
  • Histología
  • Biología celular

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