Wnt signaling modulates pre- and postsynaptic maturation: Therapeutic considerations

Ginny G. Farías, Juan A. Godoy, Waldo Cerpa, Lorena Varela-Nallar, Nibaldo C. Inestrosa

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

24 Citas (Scopus)

Resumen

Wnt signaling regulates a wealth of aspects of nervous system development and function in embryonic stages and in adulthood. The expression of Wnt ligands and components of the Wnt signaling machinery in early stages of neural development has been related to its role in neurite patterning and in synaptogenesis. Moreover, its expression in the mature nervous system suggests a role for this pathway in synaptic maintenance and function. Therefore, it is of crucial relevance the understanding of the mechanisms by which Wnt signaling regulates these processes. Herein, we discuss how different Wnt ligands, acting through different Wnt signaling pathways, operate in pre- and postsynaptic regions to modulate synapse structure and function. We also elaborate on the idea that Wnt signaling pathways are a target for the treatment of neurodegenerative diseases that affect synaptic integrity, such as Alzheimer's disease.

Idioma originalInglés
Páginas (desde-hasta)94-101
Número de páginas8
PublicaciónDevelopmental Dynamics
Volumen239
N.º1
DOI
EstadoPublicada - ene 2010

Áreas temáticas de ASJC Scopus

  • Biología del desarrollo

Huella

Profundice en los temas de investigación de 'Wnt signaling modulates pre- and postsynaptic maturation: Therapeutic considerations'. En conjunto forman una huella única.

Citar esto