Wnt signaling involvement in β-amyloid-dependent neurodegeneration

Nibaldo C. Inestrosa; Giancarlo V. De Ferrari; José L. Garrido; Alejandra Alvarez; Gonzalo H. Olivares; María I. Barría; Miguel Bronfman; Marcelo A. Chacón

doi:10.1016/S0197-0186(02)00056-6

Wnt signaling involvement in β-amyloid-dependent neurodegeneration

Nibaldo C. Inestrosa, Giancarlo V. De Ferrari, José L. Garrido, Alejandra Alvarez, Gonzalo H. Olivares, María I. Barría, Miguel Bronfman, Marcelo A. Chacón

Facultad de Ciencias de la Vida

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

79 Citas (Scopus)

Resumen

Alzheimer's disease (AD) is a progressive dementia paralleled by selective neuronal death, which is probably caused by the cytotoxic effects of the amyloid-β peptide (Aβ). We have observed that Aβ-dependent neurotoxicity induces a loss of function of Wnt signaling components and that activation of this signaling cascade prevent such cytotoxic effects. Therefore we propose that compounds which mimic this signaling cascade may be candidates for therapeutic intervention in Alzheimer's patients.

Idioma original	Inglés
Páginas (desde-hasta)	341-344
Número de páginas	4
Publicación	Neurochemistry International
Volumen	41
N.º	5
DOI	https://doi.org/10.1016/S0197-0186(02)00056-6
Estado	Publicada - 28 ago. 2002

Áreas temáticas de ASJC Scopus

Neurociencia celular y molecular
Biología celular

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@article{cd7cb664efd44b579192a045775b897a,

title = "Wnt signaling involvement in β-amyloid-dependent neurodegeneration",

abstract = "Alzheimer's disease (AD) is a progressive dementia paralleled by selective neuronal death, which is probably caused by the cytotoxic effects of the amyloid-β peptide (Aβ). We have observed that Aβ-dependent neurotoxicity induces a loss of function of Wnt signaling components and that activation of this signaling cascade prevent such cytotoxic effects. Therefore we propose that compounds which mimic this signaling cascade may be candidates for therapeutic intervention in Alzheimer's patients.",

keywords = "β-Amyloid, Neurodegeneration, Wnt signaling",

author = "Inestrosa, {Nibaldo C.} and {De Ferrari}, {Giancarlo V.} and Garrido, {Jos{\'e} L.} and Alejandra Alvarez and Olivares, {Gonzalo H.} and Barr{\'i}a, {Mar{\'i}a I.} and Miguel Bronfman and Chac{\'o}n, {Marcelo A.}",

year = "2002",

month = aug,

day = "28",

doi = "10.1016/S0197-0186(02)00056-6",

language = "English",

volume = "41",

pages = "341--344",

journal = "Neurochemistry International",

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TY - JOUR

T1 - Wnt signaling involvement in β-amyloid-dependent neurodegeneration

AU - Inestrosa, Nibaldo C.

AU - De Ferrari, Giancarlo V.

AU - Garrido, José L.

AU - Alvarez, Alejandra

AU - Olivares, Gonzalo H.

AU - Barría, María I.

AU - Bronfman, Miguel

AU - Chacón, Marcelo A.

PY - 2002/8/28

Y1 - 2002/8/28

N2 - Alzheimer's disease (AD) is a progressive dementia paralleled by selective neuronal death, which is probably caused by the cytotoxic effects of the amyloid-β peptide (Aβ). We have observed that Aβ-dependent neurotoxicity induces a loss of function of Wnt signaling components and that activation of this signaling cascade prevent such cytotoxic effects. Therefore we propose that compounds which mimic this signaling cascade may be candidates for therapeutic intervention in Alzheimer's patients.

AB - Alzheimer's disease (AD) is a progressive dementia paralleled by selective neuronal death, which is probably caused by the cytotoxic effects of the amyloid-β peptide (Aβ). We have observed that Aβ-dependent neurotoxicity induces a loss of function of Wnt signaling components and that activation of this signaling cascade prevent such cytotoxic effects. Therefore we propose that compounds which mimic this signaling cascade may be candidates for therapeutic intervention in Alzheimer's patients.

KW - β-Amyloid

KW - Neurodegeneration

KW - Wnt signaling

UR - http://www.scopus.com/inward/record.url?scp=0035993234&partnerID=8YFLogxK

U2 - 10.1016/S0197-0186(02)00056-6

DO - 10.1016/S0197-0186(02)00056-6

M3 - Article

C2 - 12176076

AN - SCOPUS:0035993234

VL - 41

SP - 341

EP - 344

JO - Neurochemistry International

JF - Neurochemistry International

SN - 0197-0186

IS - 5

ER -

Wnt signaling involvement in β-amyloid-dependent neurodegeneration

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