Wnt-5a is a synaptogenic factor with neuroprotective properties against Aβ toxicity

Lorena Varela-Nallar, Jorge Parodi, Ginny G. Farías, Nibaldo C. Inestrosa

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

24 Citas (Scopus)

Resumen

Background: We have recently found that Wnt-5a regulates the synaptic structure and function in hippocampal neurons. This ligand is expressed in the hippocampus, stimulates dendritic spine morphogenesis and increases glutamatergic neurotransmission. Moreover, we have also shown that Wnt-5a induces the clustering of PSD-95. Objective: To explore the role of Wnt-5a in the formation of synaptic contacts. Methods: Primary rat hippocampal neurons were exposed to a formylated hexapeptide (Foxy-5) derived from the sequence of Wnt-5a to study synapse formation and function. Results: In short-term experiments, Wnt-5a only induced the clustering of PSD-95 but had no effect on the density of presynaptic puncta, while in long-term experiments, it induced both pre- and postsynaptic protein clustering and the number of synaptic contacts, in agreement with electrophysiological studies. In long-term experiments, Foxy-5 increased miniature excitatory postsynaptic current amplitude and frequency. Conclusion: Our findings indicate that Wnt-5a induces synapse formation in hippocampal neurons. In addition, we discuss recent findings indicating a neuroprotective action of Wnt-5a against Aβ neurotoxicity.

Idioma originalInglés
Páginas (desde-hasta)23-26
Número de páginas4
PublicaciónNeurodegenerative Diseases
Volumen10
N.º1-4
DOI
EstadoPublicada - abr 2012

Áreas temáticas de ASJC Scopus

  • Neurología clínica
  • Neurología

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