Vitamin D control of gene expression: Temporal and spatial parameters for organization of the regulatory machinery

Martin Montecino, Gary S. Stein, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Loreto Carvallo, Sylvain Marcellini, Fernando Cruzat, Gloria Arriagada

Resultado de la investigación: Contribución a una revistaArtículo de revisión

18 Citas (Scopus)

Resumen

Vitamin D is a principal modulator of skeletal gene expression, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiologic responsiveness requires combinatorial control, whereas coregulatory proteins determine the specificity of biologic responsiveness to physiologic cues. It is becoming increasingly evident that regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.

Idioma originalInglés
Páginas (desde-hasta)163-172
Número de páginas10
PublicaciónCritical Reviews in Eukaryotic Gene Expression
Volumen18
N.º2
EstadoPublicada - 2008

Áreas temáticas de ASJC Scopus

  • Biología molecular
  • Genética

Huella Profundice en los temas de investigación de 'Vitamin D control of gene expression: Temporal and spatial parameters for organization of the regulatory machinery'. En conjunto forman una huella única.

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    Montecino, M., Stein, G. S., Stein, J. L., Lian, J. B., Van Wijnen, A. J., Carvallo, L., Marcellini, S., Cruzat, F., & Arriagada, G. (2008). Vitamin D control of gene expression: Temporal and spatial parameters for organization of the regulatory machinery. Critical Reviews in Eukaryotic Gene Expression, 18(2), 163-172.