Vitamin D control of gene expression: Temporal and spatial parameters for organization of the regulatory machinery

Martin Montecino, Gary S. Stein, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Loreto Carvallo, Sylvain Marcellini, Fernando Cruzat, Gloria Arriagada

Resultado de la investigación: Review article

17 Citas (Scopus)

Resumen

Vitamin D is a principal modulator of skeletal gene expression, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiologic responsiveness requires combinatorial control, whereas coregulatory proteins determine the specificity of biologic responsiveness to physiologic cues. It is becoming increasingly evident that regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.

Idioma originalEnglish
Páginas (desde-hasta)163-172
Número de páginas10
PublicaciónCritical Reviews in Eukaryotic Gene Expression
Volumen18
N.º2
EstadoPublished - 2008

Huella dactilar

Vitamin D
Gene Expression
Calcitriol Receptors
Cues
Proteins
Steroids
Hormones
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Citar esto

Montecino, Martin ; Stein, Gary S. ; Stein, Janet L. ; Lian, Jane B. ; Van Wijnen, Andre J. ; Carvallo, Loreto ; Marcellini, Sylvain ; Cruzat, Fernando ; Arriagada, Gloria. / Vitamin D control of gene expression : Temporal and spatial parameters for organization of the regulatory machinery. En: Critical Reviews in Eukaryotic Gene Expression. 2008 ; Vol. 18, N.º 2. pp. 163-172.
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abstract = "Vitamin D is a principal modulator of skeletal gene expression, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiologic responsiveness requires combinatorial control, whereas coregulatory proteins determine the specificity of biologic responsiveness to physiologic cues. It is becoming increasingly evident that regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.",
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author = "Martin Montecino and Stein, {Gary S.} and Stein, {Janet L.} and Lian, {Jane B.} and {Van Wijnen}, {Andre J.} and Loreto Carvallo and Sylvain Marcellini and Fernando Cruzat and Gloria Arriagada",
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Montecino, M, Stein, GS, Stein, JL, Lian, JB, Van Wijnen, AJ, Carvallo, L, Marcellini, S, Cruzat, F & Arriagada, G 2008, 'Vitamin D control of gene expression: Temporal and spatial parameters for organization of the regulatory machinery', Critical Reviews in Eukaryotic Gene Expression, vol. 18, n.º 2, pp. 163-172.

Vitamin D control of gene expression : Temporal and spatial parameters for organization of the regulatory machinery. / Montecino, Martin; Stein, Gary S.; Stein, Janet L.; Lian, Jane B.; Van Wijnen, Andre J.; Carvallo, Loreto; Marcellini, Sylvain; Cruzat, Fernando; Arriagada, Gloria.

En: Critical Reviews in Eukaryotic Gene Expression, Vol. 18, N.º 2, 2008, p. 163-172.

Resultado de la investigación: Review article

TY - JOUR

T1 - Vitamin D control of gene expression

T2 - Temporal and spatial parameters for organization of the regulatory machinery

AU - Montecino, Martin

AU - Stein, Gary S.

AU - Stein, Janet L.

AU - Lian, Jane B.

AU - Van Wijnen, Andre J.

AU - Carvallo, Loreto

AU - Marcellini, Sylvain

AU - Cruzat, Fernando

AU - Arriagada, Gloria

PY - 2008

Y1 - 2008

N2 - Vitamin D is a principal modulator of skeletal gene expression, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiologic responsiveness requires combinatorial control, whereas coregulatory proteins determine the specificity of biologic responsiveness to physiologic cues. It is becoming increasingly evident that regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.

AB - Vitamin D is a principal modulator of skeletal gene expression, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiologic responsiveness requires combinatorial control, whereas coregulatory proteins determine the specificity of biologic responsiveness to physiologic cues. It is becoming increasingly evident that regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.

KW - Chromatin

KW - Osteoblasts

KW - Transcription

KW - Vitamin D receptor

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