Virulence and antifungal therapy of murine disseminated infection by Rhodotorula mucilaginosa

Pamela Thomson, Loida López-Fernández, Josep Guarro, Javier Capilla

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

Rhodotorula infections have emerged in recent years causing mainly fungemia associated to high mortality. We have evaluated the in vitro activity of nine antifungal drugs against four clinical strains of Rhodotorula mucilaginosa, being amphotericin B, voriconazole and posaconazole the most active compounds. The experimental virulence of this fungus and the efficacy of the three mentioned drugs were evaluated in disseminated infections in neutropenic mice. Infection resulted in a high fungal load in all the organs studied without evident particular tropism. All treated animals showed reduced burden respect to the control in a strain dependent manner being voriconazole slightly superior to posaconazole and amphotericin B.

Idioma originalInglés
Páginas (desde-hasta)47-51
Número de páginas5
PublicaciónDiagnostic Microbiology and Infectious Disease
Volumen89
N.º1
DOI
EstadoPublicada - sep 2017
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Microbiología (médica)
  • Enfermedades infecciosas

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