Vaccination strategies to prevent emerging diseases for Spanish aquaculture

J. L. Romalde, C. Ravelo, S. López-Romalde, R. Avendaño-Herrera, B. Magariños, A. E. Toranzo

Resultado de la investigación: Contribución a los tipos de informe/libroContribución a la conferencia

24 Citas (Scopus)

Resumen

In recent years, three serious diseases have emerged in Spanish aquaculture. These are lactococcosis caused by Lactococcus garvieae, which is of economical importance in rainbow trout (Oncorhynchus mykiss); pseudomonadiasis caused by Pseudomonas anguilliseptica which affects gilthead seabream (Sparus aurata) and turbot (Scophthalmus maximus); and flexibacteriosis caused by Tenacibaculum maritimum which became a devastating problem in the emerging culture of sole (Solea spp). To obtain useful information for the design and development of new vaccines, antigenic characterisation of representative strains was performed. In this work we present the strategies adopted for the vaccine formulation (strains included, use of adjuvants) and administration (route, necessity of booster, etc.). The results from laboratory and/or field vaccination trials performed showed that for lactococcosis, protection lasting for five months was obtained with an oil-adjuvanted bacterin formulation. Unadjuvanted bacterin gave only a short duration of protection, which could, however, be prolonged by an antigen boost administered via the feed. A bacterin against Pseudomonas anguilliseptica gave protection for 12 weeks when tested in an experimental challenge trial in turbot. Besides the flexibacteriosis vaccine developed by our group for turbot, and due to the antigenic host-associated variability within T. maritimum, a new bacterin was developed against this bacterium to be used specifically in sole. This new bacterin, administered to sole by intraperitoneal injection, yielded RPS values of 94 % six weeks after immunization. In conclusion, these results suggest that vaccination constitutes a cost-effective method of controlling diseases that have emerged in the most important fish species being cultured in Spain.

Idioma originalInglés
Título de la publicación alojadaProgress in Fish Vaccinology
Páginas85-95
Número de páginas11
EstadoPublicada - 9 dic 2005

Serie de la publicación

NombreDevelopments in Biologicals
Volumen121
ISSN (versión impresa)1424-6074

Áreas temáticas de ASJC Scopus

  • Biomateriales
  • Inmunología
  • Farmacología

Huella Profundice en los temas de investigación de 'Vaccination strategies to prevent emerging diseases for Spanish aquaculture'. En conjunto forman una huella única.

  • Citar esto

    Romalde, J. L., Ravelo, C., López-Romalde, S., Avendaño-Herrera, R., Magariños, B., & Toranzo, A. E. (2005). Vaccination strategies to prevent emerging diseases for Spanish aquaculture. En Progress in Fish Vaccinology (pp. 85-95). (Developments in Biologicals; Vol. 121).