Updates on Clostridium difficile spore biology

Fernando Gil, Sebastián Lagos-Moraga, Paulina Calderón-Romero, Marjorie Pizarro-Guajardo, Daniel Paredes-Sabja

Resultado de la investigación: Article

13 Citas (Scopus)

Resumen

Clostridium difficile is a Gram-positive, anaerobic spore former, and an important nosocomial pathogenic bacterium. C. difficile spores are the morphotype of transmission and recurrence of the disease. The formation of C. difficile spores and their subsequent germination are essential processes during the infection. Recent in vitro and in vivo work has shed light on how spores are formed and the timing of in vivo sporulation in a mouse model. Advances have also been made in our understanding of the machineries involved in spore germination, and how antibiotic-induced dysbiosis affects the metabolism of bile salts and thus impacts C. difficile germination in vivo. Studies have also attempted to identify how C. difficile spores interact with the host's intestinal mucosa. Spore resistance has also been revisited by several groups highlighting the extreme resistance of this morphotype to traditional food processing regimes and disinfectants used in clinical settings. Therefore, the aim of this review is to summarize recent advances on spore formation/germination in vitro and in vivo, spore-host interactions, and spore resistance that contribute to our knowledge of the role of C. difficile spores in the infectious process.

Idioma originalEnglish
Páginas (desde-hasta)3-9
Número de páginas7
PublicaciónAnaerobe
Volumen45
DOI
EstadoPublished - 1 jun 2017

Huella dactilar

Clostridium difficile
Spores
Germination
Dysbiosis
Food Handling
Disinfectants
Intestinal Mucosa
Bile Acids and Salts
Anti-Bacterial Agents
Bacteria
Recurrence

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

Citar esto

Gil, Fernando ; Lagos-Moraga, Sebastián ; Calderón-Romero, Paulina ; Pizarro-Guajardo, Marjorie ; Paredes-Sabja, Daniel. / Updates on Clostridium difficile spore biology. En: Anaerobe. 2017 ; Vol. 45. pp. 3-9.
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abstract = "Clostridium difficile is a Gram-positive, anaerobic spore former, and an important nosocomial pathogenic bacterium. C. difficile spores are the morphotype of transmission and recurrence of the disease. The formation of C. difficile spores and their subsequent germination are essential processes during the infection. Recent in vitro and in vivo work has shed light on how spores are formed and the timing of in vivo sporulation in a mouse model. Advances have also been made in our understanding of the machineries involved in spore germination, and how antibiotic-induced dysbiosis affects the metabolism of bile salts and thus impacts C. difficile germination in vivo. Studies have also attempted to identify how C. difficile spores interact with the host's intestinal mucosa. Spore resistance has also been revisited by several groups highlighting the extreme resistance of this morphotype to traditional food processing regimes and disinfectants used in clinical settings. Therefore, the aim of this review is to summarize recent advances on spore formation/germination in vitro and in vivo, spore-host interactions, and spore resistance that contribute to our knowledge of the role of C. difficile spores in the infectious process.",
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Gil, F, Lagos-Moraga, S, Calderón-Romero, P, Pizarro-Guajardo, M & Paredes-Sabja, D 2017, 'Updates on Clostridium difficile spore biology', Anaerobe, vol. 45, pp. 3-9. https://doi.org/10.1016/j.anaerobe.2017.02.018

Updates on Clostridium difficile spore biology. / Gil, Fernando; Lagos-Moraga, Sebastián; Calderón-Romero, Paulina; Pizarro-Guajardo, Marjorie; Paredes-Sabja, Daniel.

En: Anaerobe, Vol. 45, 01.06.2017, p. 3-9.

Resultado de la investigación: Article

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AU - Paredes-Sabja, Daniel

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