Understanding respiratory syncytial virus infection to improve treatment and immunity

P. A. González, L. J. Carreño, S. M. Bueno, C. A. Riedel, A. M. Kalergis

Resultado de la investigación: Contribución a una revistaArtículo de revisión

12 Citas (Scopus)

Resumen

Despite significant research since it was discovered more than 50 years ago, respiratory syncytial virus (RSV) continues to be the leading agent causing infant hospitalization and respiratory distress worldwide. Although RSV normally does not cause mortality, this virus is recognized as a major public health and economic burden around the globe. RSV can modulate host immunity leading to an inflammatory response that produces lung damage and virus dissemination in the host airways. Remarkably, infection with the virus elicits poor immunity that in most cases fails to protect against subsequent exposures. Here, we review advances made on the understanding of the lifecycle of the virus, some of the molecular mechanisms it has evolved to cause pathology and ineffective immunity during infection. Hopefully, ongoing research will contribute to developing new drugs and candidate vaccines that will decrease the health burden caused by this virus.

Idioma originalInglés
Páginas (desde-hasta)1122-1139
Número de páginas18
PublicaciónCurrent Molecular Medicine
Volumen13
N.º7
DOI
EstadoPublicada - 15 ago 2013

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Medicina molecular
  • Biología molecular

Huella Profundice en los temas de investigación de 'Understanding respiratory syncytial virus infection to improve treatment and immunity'. En conjunto forman una huella única.

  • Citar esto