TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway

Ricardo Armisén, Katherine Marcelain, Felipe Simon, Julio C. Tapia, Jessica Toro, Andrew F.G. Quest, Andrés Stutzin

Resultado de la investigación: Article

35 Citas (Scopus)

Resumen

Altered expression of some members of the TRP ion channel superfamily has been associated with the development of pathologies like cancer. In particular, TRPM4 levels are reportedly elevated in diffuse large B-cell non-Hodgkin lymphoma, prostate, and cervical cancer. However, whether such changes in TRPM4 expression may be relevant to genesis or progression of cancer remains unknown. Here we show that reducing TRPM4 expression decreases proliferation of HeLa cells, a cervical cancer-derived cell line. In this cell line, constitutive TRPM4 silencing promoted GSK-3β-dependent degradation of β-catenin and reduced β-catenin/Tcf/Lef-dependent transcription. Conversely, overexpression of TRPM4 in T-REx 293 cells (a HEK293-derived cell line) increased cell proliferation and β-catenin levels. Our results identify TRPM4 as an important, unanticipated regulator of the β-catenin pathway, where aberrant signaling is frequently associated with cancer.

Idioma originalEnglish
Páginas (desde-hasta)103-109
Número de páginas7
PublicaciónJournal of Cellular Physiology
Volumen226
N.º1
DOI
EstadoPublished - ene 2011

Huella dactilar

Catenins
Cell proliferation
Up-Regulation
Cells
Cell Proliferation
Cell Line
Uterine Cervical Neoplasms
Glycogen Synthase Kinase 3
Neoplasms
HEK293 Cells
B-Cell Lymphoma
Pathology
Transcription
Ion Channels
HeLa Cells
Non-Hodgkin's Lymphoma
Prostatic Neoplasms
Degradation

ASJC Scopus subject areas

  • Medicine(all)
  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Citar esto

Armisén, R., Marcelain, K., Simon, F., Tapia, J. C., Toro, J., Quest, A. F. G., & Stutzin, A. (2011). TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway. Journal of Cellular Physiology, 226(1), 103-109. https://doi.org/10.1002/jcp.22310
Armisén, Ricardo ; Marcelain, Katherine ; Simon, Felipe ; Tapia, Julio C. ; Toro, Jessica ; Quest, Andrew F.G. ; Stutzin, Andrés. / TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway. En: Journal of Cellular Physiology. 2011 ; Vol. 226, N.º 1. pp. 103-109.
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abstract = "Altered expression of some members of the TRP ion channel superfamily has been associated with the development of pathologies like cancer. In particular, TRPM4 levels are reportedly elevated in diffuse large B-cell non-Hodgkin lymphoma, prostate, and cervical cancer. However, whether such changes in TRPM4 expression may be relevant to genesis or progression of cancer remains unknown. Here we show that reducing TRPM4 expression decreases proliferation of HeLa cells, a cervical cancer-derived cell line. In this cell line, constitutive TRPM4 silencing promoted GSK-3β-dependent degradation of β-catenin and reduced β-catenin/Tcf/Lef-dependent transcription. Conversely, overexpression of TRPM4 in T-REx 293 cells (a HEK293-derived cell line) increased cell proliferation and β-catenin levels. Our results identify TRPM4 as an important, unanticipated regulator of the β-catenin pathway, where aberrant signaling is frequently associated with cancer.",
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Armisén, R, Marcelain, K, Simon, F, Tapia, JC, Toro, J, Quest, AFG & Stutzin, A 2011, 'TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway', Journal of Cellular Physiology, vol. 226, n.º 1, pp. 103-109. https://doi.org/10.1002/jcp.22310

TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway. / Armisén, Ricardo; Marcelain, Katherine; Simon, Felipe; Tapia, Julio C.; Toro, Jessica; Quest, Andrew F.G.; Stutzin, Andrés.

En: Journal of Cellular Physiology, Vol. 226, N.º 1, 01.2011, p. 103-109.

Resultado de la investigación: Article

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AU - Quest, Andrew F.G.

AU - Stutzin, Andrés

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