Tratamiento farmacológico para las conductas desafiantes en adultos con discapacidad intelectual: revisión sistemática y metaanálisis

Rodrigo Campos-Jara, Cristian Martínez-Salazar, Christian Campos-Jara, José María Fernández, Darío Martínez-García, Falonn Contreras-Osorio

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva


Introduction: Few evidence on the use of antipsychotics in people with intellectual disabilities and challenging behaviors, generates the need to develop studies that contribute to collect, compare and synthesize the available information. The present systematic review and meta-analysis aims to determine the clinical efficacy of antipsychotic medication in reducing critical episodes in this population. Methods: We searched Web of Science, Scopus, EBSCO, Embase, and PubMed for randomized controlled trials of antipsychotic medication versus placebo. Preliminarily yielded 1354 abstracts and citations; six studies with 274 subjects met the inclusion criteria of studies with experimental design, longitudinal type, with pre- and post-intervention measurements. Results: There is evidence for the use of psychotropic drugs in the acute management of challenging behaviors in patients with intellectual disability (SMD = −0.85; 95% CI = −1.69 to −0.01; p = 0.05). Conclusions: Our results coincide with the recommendations on the efficacy of the use of antipsychotics. Although our study provides evidence, the limited number of studies included in this research does not allow us to obtain totally conclusive results, although it can be considered as a guide for future studies.

Título traducido de la contribuciónPharmacological treatment for challenging behavior in adults with intellectual disability: Systematic review and meta-analysis
Idioma originalEspañol
PublicaciónRevista de Psiquiatria y Salud Mental
EstadoEn prensa - 2023

Palabras clave

  • Challenging behavior
  • Intellectual disability
  • Pharmacological treatment

Áreas temáticas de ASJC Scopus

  • Psiquiatría y salud mental


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