Transfersomes as alternative topical nanodosage forms for the treatment of skin disorders

Pablo Oyarzún, Eduardo Gallardo-Toledo, Javier Morales, Francisco Arriagada

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

8 Citas (Scopus)

Resumen

Topical drug delivery is a promising approach to treat different skin disorders. However, it remains a challenge mainly due to the nature and rigidity of the nanosystems, which limit deep skin penetration, and the unsuccessful demonstration of clinical benefits; greater penetration by itself, does not ensure pharmacological success. In this context, transfersomes have appeared as promising nanosystems; deformability, their unique characteristic, allows them to pass through the epidermal microenvironment, improving the skin drug delivery. This review focuses on the comparison of transfersomes with other nanosystems (e.g., liposomes), discusses recent therapeutic applications for the topical treatment of different skin disorders and highlights the need for further studies to demonstrate significant clinical benefits of transfersomes compared with conventional therapies.

Idioma originalInglés
Páginas (desde-hasta)2465-2489
Número de páginas25
PublicaciónNanomedicine
Volumen16
N.º27
DOI
EstadoPublicada - nov. 2021
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Bioingeniería
  • Medicina (miscelánea)
  • Ingeniería biomédica
  • Ciencia de los Materiales General

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