Transcriptional dynamics of immune, growth and stress related genes in skeletal muscle of the fine flounder (Paralichthys adpersus) during different nutritional statuses

Cristián A. Valenzuela, Daniela Escobar, Lorena Perez, Rodrigo Zuloaga, Juan Manuel Estrada, Luis Mercado, Juan Antonio Valdés, Alfredo Molina

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

16 Citas (Scopus)

Resumen

The effects of stress on immune activity and growth in early vertebrates have not been studied in detail. The present study used fine flounder (Paralichthys adspersus) skeletal muscle as a model to evaluate molecules involved in the stress response, including the glucocorticoid receptors, foxo1/3, and the target genes of these. Additionally, immune markers (il-1β and tnfα) and effector molecules of atrophy (. bnip3, caspase-3, and lc3) were assessed. These molecules were analyzed during periods of long-term fasting and refeeding. During fasting, gene expression related to the stress response and atrophy increased; whereas immune markers were down-regulated. During refeeding, atrophy- and stress-related gene expression significantly decreased. In contrast, immune markers were up-regulated. These results provide novel insight on the control of growth in the skeletal muscle of a non-mammalian species under a stressful condition, suggesting that growth, stress, and immune activity in muscle are closely related and coordinated by orchestrated transcriptional dynamics.

Idioma originalInglés
Páginas (desde-hasta)145-157
Número de páginas13
PublicaciónDevelopmental and Comparative Immunology
Volumen53
N.º1
DOI
EstadoPublicada - 2015

Áreas temáticas de ASJC Scopus

  • Inmunología
  • Biología del desarrollo

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