Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je Yong Choi, Syed A. Ali, Sandhya Pande, Mohammad Q. Hassan

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

19 Citas (Scopus)

Resumen

Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.

Idioma originalInglés
Páginas (desde-hasta)1-6
Número de páginas6
PublicaciónBiochemistry and Cell Biology
Volumen87
N.º1
DOI
EstadoPublicada - feb. 2009

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Biología molecular
  • Biología celular

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