Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

Gary S. Stein; Sayyed K. Zaidi; Janet L. Stein; Jane B. Lian; Andre J. Van Wijnen; Martin Montecino; Daniel W. Young; Amjad Javed; Jitesh Pratap; Je Yong Choi; Syed A. Ali; Sandhya Pande; Mohammad Q. Hassan

doi:10.1139/O08-094

Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je Yong Choi, Syed A. Ali, Sandhya Pande, Mohammad Q. Hassan

Facultad de Ciencias de la Vida

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

20 Citas (Scopus)

Resumen

Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.

Idioma original	Inglés
Páginas (desde-hasta)	1-6
Número de páginas	6
Publicación	Biochemistry and Cell Biology
Volumen	87
N.º	1
DOI	https://doi.org/10.1139/O08-094
Estado	Publicada - feb. 2009

Áreas temáticas de ASJC Scopus

Bioquímica
Biología molecular
Biología celular

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title = "Transcription-factor-mediated epigenetic control of cell fate and lineage commitment",

abstract = "Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.",

keywords = "Cell cycle, Chromatin, Gene expression, Intranuclear trafficking, Nuclear microenvironment, Runx",

author = "Stein, {Gary S.} and Zaidi, {Sayyed K.} and Stein, {Janet L.} and Lian, {Jane B.} and {Van Wijnen}, {Andre J.} and Martin Montecino and Young, {Daniel W.} and Amjad Javed and Jitesh Pratap and Choi, {Je Yong} and Ali, {Syed A.} and Sandhya Pande and Hassan, {Mohammad Q.}",

year = "2009",

month = feb,

doi = "10.1139/O08-094",

language = "English",

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T1 - Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

AU - Stein, Gary S.

AU - Zaidi, Sayyed K.

AU - Stein, Janet L.

AU - Lian, Jane B.

AU - Van Wijnen, Andre J.

AU - Montecino, Martin

AU - Young, Daniel W.

AU - Javed, Amjad

AU - Pratap, Jitesh

AU - Choi, Je Yong

AU - Ali, Syed A.

AU - Pande, Sandhya

AU - Hassan, Mohammad Q.

PY - 2009/2

Y1 - 2009/2

N2 - Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.

AB - Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.

KW - Cell cycle

KW - Chromatin

KW - Gene expression

KW - Intranuclear trafficking

KW - Nuclear microenvironment

KW - Runx

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U2 - 10.1139/O08-094

DO - 10.1139/O08-094

M3 - Review article

C2 - 19234518

AN - SCOPUS:65249129828

SN - 0829-8211

VL - 87

SP - 1

EP - 6

JO - Biochemistry and Cell Biology

JF - Biochemistry and Cell Biology

IS - 1

ER -

Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

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