Toxicología Ambiental: Metalotioneínas y metabolismo celular

Cristian Oliver, Andrés Porta

Resultado de la investigación: Article

3 Citas (Scopus)

Resumen

Metallothioneins (MT) are a proteins family characterized by low molecular weight (6-8 kDa), high content of cysteine (30-35 %) and heavy metal complexation properties. Many functions have been reported, from a primary role of essential heavy metals cellular homeostasis (cytosolic pool of zinc and copper), non-essential heavy metals detoxification, inflammation and free radicals inactivation. Changes of MT concentration is a indicator of xenobiotic exposition, adverse environmental situations and physiologic stress. This modification can be applied both in clinical and working toxicology, and ecotoxicologic approaches. Environmental application is on experimental phase. This review has been focused on main evidences of metallothionein functions in cellular metabolism, both in stressed and non-stressed organisms. Despite higher number of very specific works on metallothionein its main cellular function remains unclear.

Idioma originalSpanish
Páginas (desde-hasta)363-376
Número de páginas14
PublicaciónActa Bioquimica Clinica Latinoamericana
Volumen32
N.º3
EstadoPublished - 1 dic 1998

ASJC Scopus subject areas

  • Clinical Biochemistry

Citar esto

Oliver, Cristian ; Porta, Andrés. / Toxicología Ambiental : Metalotioneínas y metabolismo celular. En: Acta Bioquimica Clinica Latinoamericana. 1998 ; Vol. 32, N.º 3. pp. 363-376.
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abstract = "Metallothioneins (MT) are a proteins family characterized by low molecular weight (6-8 kDa), high content of cysteine (30-35 {\%}) and heavy metal complexation properties. Many functions have been reported, from a primary role of essential heavy metals cellular homeostasis (cytosolic pool of zinc and copper), non-essential heavy metals detoxification, inflammation and free radicals inactivation. Changes of MT concentration is a indicator of xenobiotic exposition, adverse environmental situations and physiologic stress. This modification can be applied both in clinical and working toxicology, and ecotoxicologic approaches. Environmental application is on experimental phase. This review has been focused on main evidences of metallothionein functions in cellular metabolism, both in stressed and non-stressed organisms. Despite higher number of very specific works on metallothionein its main cellular function remains unclear.",
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Toxicología Ambiental : Metalotioneínas y metabolismo celular. / Oliver, Cristian; Porta, Andrés.

En: Acta Bioquimica Clinica Latinoamericana, Vol. 32, N.º 3, 01.12.1998, p. 363-376.

Resultado de la investigación: Article

TY - JOUR

T1 - Toxicología Ambiental

T2 - Metalotioneínas y metabolismo celular

AU - Oliver, Cristian

AU - Porta, Andrés

PY - 1998/12/1

Y1 - 1998/12/1

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KW - Cadmium

KW - Copper

KW - Free radicals

KW - Heavy metals

KW - Metallothionein

KW - Stress

KW - Thionein

KW - Zinc

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