TnpPred: A web service for the robust prediction of prokaryotic transposases

Gonzalo Riadi, Cristobal Medina-Moenne, David S. Holmes

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

27 Citas (Scopus)

Resumen

Transposases (Tnps) are enzymes that participate in the movement of insertion sequences (ISs) within and between genomes. Genes that encode Tnps are amongst the most abundant and widely distributed genes in nature. However, they are difficult to predict bioinformatically and given the increasing availability of prokaryotic genomes and metagenomes, it is incumbent to develop rapid, high quality automatic annotation of ISs. This need prompted us to develop a web service, termed TnpPred for Tnp discovery. It provides better sensitivity and specificity for Tnp predictions than given by currently available programs as determined by ROC analysis. TnpPred should be useful for improving genome annotation. The TnpPred web service is freely available for noncommercial use.

Idioma originalInglés
Número de artículo678761
PublicaciónComparative and Functional Genomics
Volumen2012
DOI
EstadoPublicada - 2012

Áreas temáticas de ASJC Scopus

  • Biotecnología
  • Biología molecular
  • Genética

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