Resumen
Muscle-specific RING finger (MuRF) proteins are E3-ubiquitin ligases and key regulators of muscle growth and turnover. Here, using a range of phylogenomic approaches, we established the complete-definitive MuRF family of vertebrates. Adding to recognized MuRF1, 2 and 3, we describe a novel family member, hereafter MuRF4, which was independently lost during placental mammal and bird evolution, but is otherwise conserved. MuRF4 transcripts were expressed in heart and skeletal muscles of zebrafish, but were barely detectable in striated muscles of adult anole lizards. We also demonstrate that MuRF1 underwent retrotransposition in the teleost fish ancestor, before the retrogene fully replaced the original gene and muscle-specific function.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 4390-4397 |
| Número de páginas | 8 |
| Publicación | FEBS Letters |
| Volumen | 588 |
| N.º | 23 |
| DOI | |
| Estado | Published - 28 nov 2014 |
Huella dactilar
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology
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The vertebrate muscle-specific RING finger protein family includes MuRF4 - A novel, conserved E3-ubiquitin ligase. / Macqueen, Daniel J.; Fuentes, Eduardo N.; Valdés, Juan Antonio; Molina, Alfredo; Martin, Samuel A.M.
En: FEBS Letters, Vol. 588, N.º 23, 28.11.2014, p. 4390-4397.Resultado de la investigación: Article
TY - JOUR
T1 - The vertebrate muscle-specific RING finger protein family includes MuRF4 - A novel, conserved E3-ubiquitin ligase
AU - Macqueen, Daniel J.
AU - Fuentes, Eduardo N.
AU - Valdés, Juan Antonio
AU - Molina, Alfredo
AU - Martin, Samuel A.M.
PY - 2014/11/28
Y1 - 2014/11/28
N2 - Muscle-specific RING finger (MuRF) proteins are E3-ubiquitin ligases and key regulators of muscle growth and turnover. Here, using a range of phylogenomic approaches, we established the complete-definitive MuRF family of vertebrates. Adding to recognized MuRF1, 2 and 3, we describe a novel family member, hereafter MuRF4, which was independently lost during placental mammal and bird evolution, but is otherwise conserved. MuRF4 transcripts were expressed in heart and skeletal muscles of zebrafish, but were barely detectable in striated muscles of adult anole lizards. We also demonstrate that MuRF1 underwent retrotransposition in the teleost fish ancestor, before the retrogene fully replaced the original gene and muscle-specific function.
AB - Muscle-specific RING finger (MuRF) proteins are E3-ubiquitin ligases and key regulators of muscle growth and turnover. Here, using a range of phylogenomic approaches, we established the complete-definitive MuRF family of vertebrates. Adding to recognized MuRF1, 2 and 3, we describe a novel family member, hereafter MuRF4, which was independently lost during placental mammal and bird evolution, but is otherwise conserved. MuRF4 transcripts were expressed in heart and skeletal muscles of zebrafish, but were barely detectable in striated muscles of adult anole lizards. We also demonstrate that MuRF1 underwent retrotransposition in the teleost fish ancestor, before the retrogene fully replaced the original gene and muscle-specific function.
KW - E3-ubiquitin ligase
KW - Evolution
KW - Muscle-specific RING finger family
KW - Novel MuRF: MuRF4
KW - Retrotransposition
KW - Striated muscle
UR - http://www.scopus.com/inward/record.url?scp=84910593029&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2014.10.008
DO - 10.1016/j.febslet.2014.10.008
M3 - Article
C2 - 25448676
AN - SCOPUS:84910593029
VL - 588
SP - 4390
EP - 4397
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 23
ER -