The vertebrate muscle-specific RING finger protein family includes MuRF4 - A novel, conserved E3-ubiquitin ligase

Daniel J. Macqueen, Eduardo N. Fuentes, Juan Antonio Valdés, Alfredo Molina, Samuel A.M. Martin

Resultado de la investigación: Article

6 Citas (Scopus)

Resumen

Muscle-specific RING finger (MuRF) proteins are E3-ubiquitin ligases and key regulators of muscle growth and turnover. Here, using a range of phylogenomic approaches, we established the complete-definitive MuRF family of vertebrates. Adding to recognized MuRF1, 2 and 3, we describe a novel family member, hereafter MuRF4, which was independently lost during placental mammal and bird evolution, but is otherwise conserved. MuRF4 transcripts were expressed in heart and skeletal muscles of zebrafish, but were barely detectable in striated muscles of adult anole lizards. We also demonstrate that MuRF1 underwent retrotransposition in the teleost fish ancestor, before the retrogene fully replaced the original gene and muscle-specific function.

Idioma originalEnglish
Páginas (desde-hasta)4390-4397
Número de páginas8
PublicaciónFEBS Letters
Volumen588
N.º23
DOI
EstadoPublished - 28 nov 2014

Huella dactilar

Ubiquitin-Protein Ligases
Muscle
Vertebrates
Muscles
Proteins
Lizards
Striated Muscle
Zebrafish
Birds
Mammals
Myocardium
Fishes
Skeletal Muscle
Fish
Growth
Genes

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Citar esto

Macqueen, Daniel J. ; Fuentes, Eduardo N. ; Valdés, Juan Antonio ; Molina, Alfredo ; Martin, Samuel A.M. / The vertebrate muscle-specific RING finger protein family includes MuRF4 - A novel, conserved E3-ubiquitin ligase. En: FEBS Letters. 2014 ; Vol. 588, N.º 23. pp. 4390-4397.
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abstract = "Muscle-specific RING finger (MuRF) proteins are E3-ubiquitin ligases and key regulators of muscle growth and turnover. Here, using a range of phylogenomic approaches, we established the complete-definitive MuRF family of vertebrates. Adding to recognized MuRF1, 2 and 3, we describe a novel family member, hereafter MuRF4, which was independently lost during placental mammal and bird evolution, but is otherwise conserved. MuRF4 transcripts were expressed in heart and skeletal muscles of zebrafish, but were barely detectable in striated muscles of adult anole lizards. We also demonstrate that MuRF1 underwent retrotransposition in the teleost fish ancestor, before the retrogene fully replaced the original gene and muscle-specific function.",
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The vertebrate muscle-specific RING finger protein family includes MuRF4 - A novel, conserved E3-ubiquitin ligase. / Macqueen, Daniel J.; Fuentes, Eduardo N.; Valdés, Juan Antonio; Molina, Alfredo; Martin, Samuel A.M.

En: FEBS Letters, Vol. 588, N.º 23, 28.11.2014, p. 4390-4397.

Resultado de la investigación: Article

TY - JOUR

T1 - The vertebrate muscle-specific RING finger protein family includes MuRF4 - A novel, conserved E3-ubiquitin ligase

AU - Macqueen, Daniel J.

AU - Fuentes, Eduardo N.

AU - Valdés, Juan Antonio

AU - Molina, Alfredo

AU - Martin, Samuel A.M.

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AB - Muscle-specific RING finger (MuRF) proteins are E3-ubiquitin ligases and key regulators of muscle growth and turnover. Here, using a range of phylogenomic approaches, we established the complete-definitive MuRF family of vertebrates. Adding to recognized MuRF1, 2 and 3, we describe a novel family member, hereafter MuRF4, which was independently lost during placental mammal and bird evolution, but is otherwise conserved. MuRF4 transcripts were expressed in heart and skeletal muscles of zebrafish, but were barely detectable in striated muscles of adult anole lizards. We also demonstrate that MuRF1 underwent retrotransposition in the teleost fish ancestor, before the retrogene fully replaced the original gene and muscle-specific function.

KW - E3-ubiquitin ligase

KW - Evolution

KW - Muscle-specific RING finger family

KW - Novel MuRF: MuRF4

KW - Retrotransposition

KW - Striated muscle

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