The Role of Specialized Pro-Resolving Lipid Mediators in Inflammation-Induced Carcinogenesis

Wheeler Torres, José Luis Pérez, María P. Díaz, Luis D’Marco, Ana Checa-Ros, Rubén Carrasquero, Lissé Angarita, Yosselin Gómez, Maricarmen Chacín, Paola Ramírez, Nelson Villasmil, Samuel Durán-Agüero, Clímaco Cano, Valmore Bermúdez

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Resumen

Cancer is a process involving cell mutation, increased proliferation, invasion, and metastasis. Over the years, this condition has represented one of the most concerning health problems worldwide due to its significant morbidity and mortality. At present, the incidence of cancer continues to grow exponentially. Thus, it is imperative to open new avenues in cancer research to understand the molecular changes driving DNA transformation, cell-to-cell interaction derangements, and immune system surveillance decay. In this regard, evidence supports the relationship between chronic inflammation and cancer. In light of this, a group of bioactive lipids derived from polyunsaturated fatty acids (PUFAs) may have a position as novel anti-inflammatory molecules known as the specialized pro-resolving mediators (SPMs), a group of pro-resolutive inflammation agents that could improve the anti-tumor immunity. These molecules have the potential role of chemopreventive and therapeutic agents for various cancer types, and their effects have been documented in the scientific literature. Thus, this review objective centers around understanding the effect of SPMs on carcinogenesis and their potential therapeutic effect.

Idioma originalInglés
Número de artículo12623
PublicaciónInternational Journal of Molecular Sciences
Volumen24
N.º16
DOI
EstadoPublicada - ago. 2023

Áreas temáticas de ASJC Scopus

  • Catálisis
  • Biología molecular
  • Espectroscopia
  • Informática aplicada
  • Química física y teórica
  • Química orgánica
  • Química inorgánica

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