The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to β-lactam antibiotics in Gram-positive and Gram-negative bacteria

Derie E. Fuentes, Claudio A. Navarro, Juan C. Tantaleán, Manuel A. Araya, Claudia P. Saavedra, José M. Pérez, Iván L. Calderón, Phil A. Youderian, Guido C. Mora, Claudio C. Vásquez

Resultado de la investigación: Contribución a una revistaArtículo

23 Citas (Scopus)

Resumen

We have characterized a natural isolate of Staphylococcus epidermidis resistant to heavy metals that carries a small 2391-bp plasmid, pSepCH, encoding the qacC gene. The S. epidermidis qacC gene confers resistance to a number of β-lactam antibiotics and to ethidium bromide in its natural host and in Escherichia coli K12 and Salmonella enterica sv. Typhimurium. This is the first communication of a small multidrug resistance (SMR) pump involved in resistance to β-lactam antibiotics. Experiments using tolC, ompW and ompD mutant strains of S. Typhimurium demonstrated that the β-lactam antibiotic resistance conferred by this pump does not depend on these outer membrane proteins.

Idioma originalInglés
Páginas (desde-hasta)472-477
Número de páginas6
PublicaciónResearch in Microbiology
Volumen156
N.º4
DOI
EstadoPublicada - 1 ene 2005

Áreas temáticas de ASJC Scopus

  • Microbiología
  • Biología molecular

Huella Profundice en los temas de investigación de 'The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to β-lactam antibiotics in Gram-positive and Gram-negative bacteria'. En conjunto forman una huella única.

  • Citar esto