The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to β-lactam antibiotics in Gram-positive and Gram-negative bacteria

Derie E. Fuentes, Claudio A. Navarro, Juan C. Tantaleán, Manuel A. Araya, Claudia P. Saavedra, José M. Pérez, Iván L. Calderón, Phil A. Youderian, Guido C. Mora, Claudio C. Vásquez

Resultado de la investigación: Article

22 Citas (Scopus)

Resumen

We have characterized a natural isolate of Staphylococcus epidermidis resistant to heavy metals that carries a small 2391-bp plasmid, pSepCH, encoding the qacC gene. The S. epidermidis qacC gene confers resistance to a number of β-lactam antibiotics and to ethidium bromide in its natural host and in Escherichia coli K12 and Salmonella enterica sv. Typhimurium. This is the first communication of a small multidrug resistance (SMR) pump involved in resistance to β-lactam antibiotics. Experiments using tolC, ompW and ompD mutant strains of S. Typhimurium demonstrated that the β-lactam antibiotic resistance conferred by this pump does not depend on these outer membrane proteins.

Idioma originalEnglish
Páginas (desde-hasta)472-477
Número de páginas6
PublicaciónResearch in Microbiology
Volumen156
N.º4
DOI
EstadoPublished - 1 ene 2005

Huella dactilar

Lactams
Staphylococcus epidermidis
Gram-Negative Bacteria
Anti-Bacterial Agents
Genes
Escherichia coli K12
Salmonella enterica
Ethidium
Multiple Drug Resistance
Microbial Drug Resistance
Heavy Metals
Membrane Proteins
Plasmids

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Citar esto

Fuentes, Derie E. ; Navarro, Claudio A. ; Tantaleán, Juan C. ; Araya, Manuel A. ; Saavedra, Claudia P. ; Pérez, José M. ; Calderón, Iván L. ; Youderian, Phil A. ; Mora, Guido C. ; Vásquez, Claudio C. / The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to β-lactam antibiotics in Gram-positive and Gram-negative bacteria. En: Research in Microbiology. 2005 ; Vol. 156, N.º 4. pp. 472-477.
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abstract = "We have characterized a natural isolate of Staphylococcus epidermidis resistant to heavy metals that carries a small 2391-bp plasmid, pSepCH, encoding the qacC gene. The S. epidermidis qacC gene confers resistance to a number of β-lactam antibiotics and to ethidium bromide in its natural host and in Escherichia coli K12 and Salmonella enterica sv. Typhimurium. This is the first communication of a small multidrug resistance (SMR) pump involved in resistance to β-lactam antibiotics. Experiments using tolC, ompW and ompD mutant strains of S. Typhimurium demonstrated that the β-lactam antibiotic resistance conferred by this pump does not depend on these outer membrane proteins.",
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The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to β-lactam antibiotics in Gram-positive and Gram-negative bacteria. / Fuentes, Derie E.; Navarro, Claudio A.; Tantaleán, Juan C.; Araya, Manuel A.; Saavedra, Claudia P.; Pérez, José M.; Calderón, Iván L.; Youderian, Phil A.; Mora, Guido C.; Vásquez, Claudio C.

En: Research in Microbiology, Vol. 156, N.º 4, 01.01.2005, p. 472-477.

Resultado de la investigación: Article

TY - JOUR

T1 - The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to β-lactam antibiotics in Gram-positive and Gram-negative bacteria

AU - Fuentes, Derie E.

AU - Navarro, Claudio A.

AU - Tantaleán, Juan C.

AU - Araya, Manuel A.

AU - Saavedra, Claudia P.

AU - Pérez, José M.

AU - Calderón, Iván L.

AU - Youderian, Phil A.

AU - Mora, Guido C.

AU - Vásquez, Claudio C.

PY - 2005/1/1

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AB - We have characterized a natural isolate of Staphylococcus epidermidis resistant to heavy metals that carries a small 2391-bp plasmid, pSepCH, encoding the qacC gene. The S. epidermidis qacC gene confers resistance to a number of β-lactam antibiotics and to ethidium bromide in its natural host and in Escherichia coli K12 and Salmonella enterica sv. Typhimurium. This is the first communication of a small multidrug resistance (SMR) pump involved in resistance to β-lactam antibiotics. Experiments using tolC, ompW and ompD mutant strains of S. Typhimurium demonstrated that the β-lactam antibiotic resistance conferred by this pump does not depend on these outer membrane proteins.

KW - Ethidium bromide

KW - Multidrug resistance

KW - qacC

KW - SMR

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