The p75 neurotrophin receptor interacts with multiple MAGE proteins

Marianna Tcherpakov, Francisca C. Bronfman, Silvestro G. Conticello, Anna Vaskovsky, Zehava Levy, Michio Niinobe, Kazuaki Yoshikawa, Ernest Arenas, Mike Fainzilber

Resultado de la investigación: Contribución a una revistaArtículo

78 Citas (Scopus)

Resumen

The p75 neurotrophin receptor has been implicated in diverse aspects of neurotrophin signaling, but the mechanisms by which its effects are mediated are not well understood. Here we identify two MAGE proteins, necdin and MAGE-H1, as interactors for the intracellular domain of p75 and show that the interaction is enhanced by ligand stimulation. PC12 cells transfected with necdin or MAGE-H1 exhibit accelerated differentiation in response to nerve growth factor. Expression of these two MAGE proteins is predominantly cytoplasmic in PC12 cells, and needin was found to be capable of homodimerization, suggesting that it may act as a cytoplasmic adaptor to recruit a signaling complex to p75. These findings indicate that diverse MAGE family members can interact with the p75 receptor and highlight type II MAGE proteins as a potential family of interactors for signaling proteins containing type II death domains.

Idioma originalInglés
Páginas (desde-hasta)49101-49104
Número de páginas4
PublicaciónJournal of Biological Chemistry
Volumen277
N.º51
DOI
EstadoPublicada - 20 dic 2002
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Biología molecular
  • Biología celular

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    Tcherpakov, M., Bronfman, F. C., Conticello, S. G., Vaskovsky, A., Levy, Z., Niinobe, M., Yoshikawa, K., Arenas, E., & Fainzilber, M. (2002). The p75 neurotrophin receptor interacts with multiple MAGE proteins. Journal of Biological Chemistry, 277(51), 49101-49104. https://doi.org/10.1074/jbc.C200533200