The orexin neuropeptide system: Physical activity and hypothalamic function throughout the aging process

Anastasia N. Zink, Claudio Esteban Perez-Leighton, Catherine M. Kotz

Resultado de la investigación: Contribución a una revistaArtículo de revisión

20 Citas (Scopus)

Resumen

There is a rising medical need for novel therapeutic targets of physical activity. Physical activity spans from spontaneous, low intensity movements to voluntary, high-intensity exercise. Regulation of spontaneous and voluntary movement is distributed over many brain areas and neural substrates, but the specific cellular and molecular mechanisms responsible for mediating overall activity levels are not well understood. The hypothalamus plays a central role in the control of physical activity, which is executed through coordination of multiple signaling systems, including the orexin neuropeptides. Orexin producing neurons integrate physiological and metabolic information to coordinate multiple behavioral states and modulate physical activity in response to the environment. This review is organized around three questions: (1) How do orexin peptides modulate physical activity? (2) What are the effects of aging and lifestyle choices on physical activity? (3) What are the effects of aging on hypothalamic function and the orexin peptides? Discussion of these questions will provide a summary of the current state of knowledge regarding hypothalamic orexin regulation of physical activity during aging and provide a platform on which to develop improved clinical outcomes in age-associated obesity and metabolic syndromes.

Idioma originalInglés
Número de artículo211
PublicaciónFrontiers in Systems Neuroscience
Volumen8
N.ºNovember
DOI
EstadoPublicada - 4 nov 2014

Áreas temáticas de ASJC Scopus

  • Neurociencia (miscelánea)
  • Neurociencia evolutiva
  • Neurociencia cognitiva
  • Neurociencia celular y molecular

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