The expression of α(v) and β3 integrin subunits in the normal human Fallopian tube epithelium suggests the occurrence of a tubal implantation window

Lorena Sülz, Juan Pablo Valenzuela, Ana María Salvatierra, María Elena Ortiz, Horacio B. Croxatto

Resultado de la investigación: Article

31 Citas (Scopus)

Resumen

The co-expression of α1β1, α4β1 and α(v)β3 integrins in the human endometrium coincides with the implantation window. The α(v)β3 integrin is expressed in the apical surface of the luminal epithelium and may serve to anchor trophoblast cells in the adhesion phase of implantation. Using immunohistochemistry, we compared the expression of α(v), α1, α4 and β3 integrin subunits in samples of normal human Fallopian tube and endometrium obtained from five women in the non-receptive period (luteal phase days 2-4) and from another five women in the receptive period (luteal phase days 6-8). The staining was quantified visually on a scale of 0 to ++, according to the intensity and density of stained cells. The α(v) subunit is expressed in the Fallopian tube epithelium during both periods in a pericellular distribution. The β3 subunit is also expressed in the same location, but it is up-regulated during the period of endometrial receptivity. The other subunits are expressed in localizations which are not relevant to trophoblast adhesion and exhibit little or no difference in the level of expression between the non-receptive and receptive periods. Based on these results we postulate that the expression of the β3 subunit in the human tubal epithelium is under the same systemic controlling signals as in the endometrium and that the normal tubal epithelium may have an implantation window, at about the same time as the endometrium, that affords the opportunity for trophoblast attachment should a 5-7 day embryo be unduly retained in the tube.

Idioma originalEnglish
Páginas (desde-hasta)2916-2920
Número de páginas5
PublicaciónHuman Reproduction
Volumen13
N.º10
DOI
EstadoPublished - 1 ene 1998

Huella dactilar

Fallopian Tubes
Endometrium
Integrins
Trophoblasts
Epithelium
Luteal Phase
Cell Adhesion
Embryonic Structures
Cell Count
Immunohistochemistry
Staining and Labeling

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Citar esto

Sülz, Lorena ; Valenzuela, Juan Pablo ; Salvatierra, Ana María ; Ortiz, María Elena ; Croxatto, Horacio B. / The expression of α(v) and β3 integrin subunits in the normal human Fallopian tube epithelium suggests the occurrence of a tubal implantation window. En: Human Reproduction. 1998 ; Vol. 13, N.º 10. pp. 2916-2920.
@article{a5d1706f384d452e92b562798327656e,
title = "The expression of α(v) and β3 integrin subunits in the normal human Fallopian tube epithelium suggests the occurrence of a tubal implantation window",
abstract = "The co-expression of α1β1, α4β1 and α(v)β3 integrins in the human endometrium coincides with the implantation window. The α(v)β3 integrin is expressed in the apical surface of the luminal epithelium and may serve to anchor trophoblast cells in the adhesion phase of implantation. Using immunohistochemistry, we compared the expression of α(v), α1, α4 and β3 integrin subunits in samples of normal human Fallopian tube and endometrium obtained from five women in the non-receptive period (luteal phase days 2-4) and from another five women in the receptive period (luteal phase days 6-8). The staining was quantified visually on a scale of 0 to ++, according to the intensity and density of stained cells. The α(v) subunit is expressed in the Fallopian tube epithelium during both periods in a pericellular distribution. The β3 subunit is also expressed in the same location, but it is up-regulated during the period of endometrial receptivity. The other subunits are expressed in localizations which are not relevant to trophoblast adhesion and exhibit little or no difference in the level of expression between the non-receptive and receptive periods. Based on these results we postulate that the expression of the β3 subunit in the human tubal epithelium is under the same systemic controlling signals as in the endometrium and that the normal tubal epithelium may have an implantation window, at about the same time as the endometrium, that affords the opportunity for trophoblast attachment should a 5-7 day embryo be unduly retained in the tube.",
keywords = "Ectopic pregnancy, Endometrium, Fallopian tube, Implantation window, Integrin",
author = "Lorena S{\"u}lz and Valenzuela, {Juan Pablo} and Salvatierra, {Ana Mar{\'i}a} and Ortiz, {Mar{\'i}a Elena} and Croxatto, {Horacio B.}",
year = "1998",
month = "1",
day = "1",
doi = "10.1093/humrep/13.10.2916",
language = "English",
volume = "13",
pages = "2916--2920",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "10",

}

The expression of α(v) and β3 integrin subunits in the normal human Fallopian tube epithelium suggests the occurrence of a tubal implantation window. / Sülz, Lorena; Valenzuela, Juan Pablo; Salvatierra, Ana María; Ortiz, María Elena; Croxatto, Horacio B.

En: Human Reproduction, Vol. 13, N.º 10, 01.01.1998, p. 2916-2920.

Resultado de la investigación: Article

TY - JOUR

T1 - The expression of α(v) and β3 integrin subunits in the normal human Fallopian tube epithelium suggests the occurrence of a tubal implantation window

AU - Sülz, Lorena

AU - Valenzuela, Juan Pablo

AU - Salvatierra, Ana María

AU - Ortiz, María Elena

AU - Croxatto, Horacio B.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - The co-expression of α1β1, α4β1 and α(v)β3 integrins in the human endometrium coincides with the implantation window. The α(v)β3 integrin is expressed in the apical surface of the luminal epithelium and may serve to anchor trophoblast cells in the adhesion phase of implantation. Using immunohistochemistry, we compared the expression of α(v), α1, α4 and β3 integrin subunits in samples of normal human Fallopian tube and endometrium obtained from five women in the non-receptive period (luteal phase days 2-4) and from another five women in the receptive period (luteal phase days 6-8). The staining was quantified visually on a scale of 0 to ++, according to the intensity and density of stained cells. The α(v) subunit is expressed in the Fallopian tube epithelium during both periods in a pericellular distribution. The β3 subunit is also expressed in the same location, but it is up-regulated during the period of endometrial receptivity. The other subunits are expressed in localizations which are not relevant to trophoblast adhesion and exhibit little or no difference in the level of expression between the non-receptive and receptive periods. Based on these results we postulate that the expression of the β3 subunit in the human tubal epithelium is under the same systemic controlling signals as in the endometrium and that the normal tubal epithelium may have an implantation window, at about the same time as the endometrium, that affords the opportunity for trophoblast attachment should a 5-7 day embryo be unduly retained in the tube.

AB - The co-expression of α1β1, α4β1 and α(v)β3 integrins in the human endometrium coincides with the implantation window. The α(v)β3 integrin is expressed in the apical surface of the luminal epithelium and may serve to anchor trophoblast cells in the adhesion phase of implantation. Using immunohistochemistry, we compared the expression of α(v), α1, α4 and β3 integrin subunits in samples of normal human Fallopian tube and endometrium obtained from five women in the non-receptive period (luteal phase days 2-4) and from another five women in the receptive period (luteal phase days 6-8). The staining was quantified visually on a scale of 0 to ++, according to the intensity and density of stained cells. The α(v) subunit is expressed in the Fallopian tube epithelium during both periods in a pericellular distribution. The β3 subunit is also expressed in the same location, but it is up-regulated during the period of endometrial receptivity. The other subunits are expressed in localizations which are not relevant to trophoblast adhesion and exhibit little or no difference in the level of expression between the non-receptive and receptive periods. Based on these results we postulate that the expression of the β3 subunit in the human tubal epithelium is under the same systemic controlling signals as in the endometrium and that the normal tubal epithelium may have an implantation window, at about the same time as the endometrium, that affords the opportunity for trophoblast attachment should a 5-7 day embryo be unduly retained in the tube.

KW - Ectopic pregnancy

KW - Endometrium

KW - Fallopian tube

KW - Implantation window

KW - Integrin

UR - http://www.scopus.com/inward/record.url?scp=0031758626&partnerID=8YFLogxK

U2 - 10.1093/humrep/13.10.2916

DO - 10.1093/humrep/13.10.2916

M3 - Article

C2 - 9804255

AN - SCOPUS:0031758626

VL - 13

SP - 2916

EP - 2920

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 10

ER -