Resumen
The co-expression of α1β1, α4β1 and α(v)β3 integrins in the human endometrium coincides with the implantation window. The α(v)β3 integrin is expressed in the apical surface of the luminal epithelium and may serve to anchor trophoblast cells in the adhesion phase of implantation. Using immunohistochemistry, we compared the expression of α(v), α1, α4 and β3 integrin subunits in samples of normal human Fallopian tube and endometrium obtained from five women in the non-receptive period (luteal phase days 2-4) and from another five women in the receptive period (luteal phase days 6-8). The staining was quantified visually on a scale of 0 to ++, according to the intensity and density of stained cells. The α(v) subunit is expressed in the Fallopian tube epithelium during both periods in a pericellular distribution. The β3 subunit is also expressed in the same location, but it is up-regulated during the period of endometrial receptivity. The other subunits are expressed in localizations which are not relevant to trophoblast adhesion and exhibit little or no difference in the level of expression between the non-receptive and receptive periods. Based on these results we postulate that the expression of the β3 subunit in the human tubal epithelium is under the same systemic controlling signals as in the endometrium and that the normal tubal epithelium may have an implantation window, at about the same time as the endometrium, that affords the opportunity for trophoblast attachment should a 5-7 day embryo be unduly retained in the tube.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 2916-2920 |
| Número de páginas | 5 |
| Publicación | Human Reproduction |
| Volumen | 13 |
| N.º | 10 |
| DOI | |
| Estado | Published - 1 ene 1998 |
Huella dactilar
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology
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The expression of α(v) and β3 integrin subunits in the normal human Fallopian tube epithelium suggests the occurrence of a tubal implantation window. / Sülz, Lorena; Valenzuela, Juan Pablo; Salvatierra, Ana María; Ortiz, María Elena; Croxatto, Horacio B.
En: Human Reproduction, Vol. 13, N.º 10, 01.01.1998, p. 2916-2920.Resultado de la investigación: Article
TY - JOUR
T1 - The expression of α(v) and β3 integrin subunits in the normal human Fallopian tube epithelium suggests the occurrence of a tubal implantation window
AU - Sülz, Lorena
AU - Valenzuela, Juan Pablo
AU - Salvatierra, Ana María
AU - Ortiz, María Elena
AU - Croxatto, Horacio B.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - The co-expression of α1β1, α4β1 and α(v)β3 integrins in the human endometrium coincides with the implantation window. The α(v)β3 integrin is expressed in the apical surface of the luminal epithelium and may serve to anchor trophoblast cells in the adhesion phase of implantation. Using immunohistochemistry, we compared the expression of α(v), α1, α4 and β3 integrin subunits in samples of normal human Fallopian tube and endometrium obtained from five women in the non-receptive period (luteal phase days 2-4) and from another five women in the receptive period (luteal phase days 6-8). The staining was quantified visually on a scale of 0 to ++, according to the intensity and density of stained cells. The α(v) subunit is expressed in the Fallopian tube epithelium during both periods in a pericellular distribution. The β3 subunit is also expressed in the same location, but it is up-regulated during the period of endometrial receptivity. The other subunits are expressed in localizations which are not relevant to trophoblast adhesion and exhibit little or no difference in the level of expression between the non-receptive and receptive periods. Based on these results we postulate that the expression of the β3 subunit in the human tubal epithelium is under the same systemic controlling signals as in the endometrium and that the normal tubal epithelium may have an implantation window, at about the same time as the endometrium, that affords the opportunity for trophoblast attachment should a 5-7 day embryo be unduly retained in the tube.
AB - The co-expression of α1β1, α4β1 and α(v)β3 integrins in the human endometrium coincides with the implantation window. The α(v)β3 integrin is expressed in the apical surface of the luminal epithelium and may serve to anchor trophoblast cells in the adhesion phase of implantation. Using immunohistochemistry, we compared the expression of α(v), α1, α4 and β3 integrin subunits in samples of normal human Fallopian tube and endometrium obtained from five women in the non-receptive period (luteal phase days 2-4) and from another five women in the receptive period (luteal phase days 6-8). The staining was quantified visually on a scale of 0 to ++, according to the intensity and density of stained cells. The α(v) subunit is expressed in the Fallopian tube epithelium during both periods in a pericellular distribution. The β3 subunit is also expressed in the same location, but it is up-regulated during the period of endometrial receptivity. The other subunits are expressed in localizations which are not relevant to trophoblast adhesion and exhibit little or no difference in the level of expression between the non-receptive and receptive periods. Based on these results we postulate that the expression of the β3 subunit in the human tubal epithelium is under the same systemic controlling signals as in the endometrium and that the normal tubal epithelium may have an implantation window, at about the same time as the endometrium, that affords the opportunity for trophoblast attachment should a 5-7 day embryo be unduly retained in the tube.
KW - Ectopic pregnancy
KW - Endometrium
KW - Fallopian tube
KW - Implantation window
KW - Integrin
UR - http://www.scopus.com/inward/record.url?scp=0031758626&partnerID=8YFLogxK
U2 - 10.1093/humrep/13.10.2916
DO - 10.1093/humrep/13.10.2916
M3 - Article
C2 - 9804255
AN - SCOPUS:0031758626
VL - 13
SP - 2916
EP - 2920
JO - Human Reproduction
JF - Human Reproduction
SN - 0268-1161
IS - 10
ER -