The essential role of chemokines in the selective regulation of lymphocyte homing

María Rosa Bono, Raúl Elgueta, Daniela Sauma, Karina Pino, Fabiola Osorio, Paula Michea, Alberto Fierro, Mario Rosemblatt

Resultado de la investigación: Contribución a una revistaArtículo

41 Citas (Scopus)

Resumen

Knowledge of lymphocyte migration has become a major issue in our understanding of acquired immunity. The selective migration of naïve, effector, memory and regulatory T-cells is a multiple step process regulated by a specific arrangement of cytokines, chemokines and adhesion receptors that guide these cells to specific locations. Recent research has outlined two major pathways of lymphocyte trafficking under homeostatic and inflammatory conditions, one concerning tropism to cutaneous tissue and a second one related to mucosal-associated sites. In this article we will outline our present understanding of the role of cytokines and chemokines as regulators of lymphocyte migration through tissues.

Idioma originalInglés
Páginas (desde-hasta)33-43
Número de páginas11
PublicaciónCytokine and Growth Factor Reviews
Volumen18
N.º1-2
DOI
EstadoPublicada - 1 feb 2007

Áreas temáticas de ASJC Scopus

  • Inmunología
  • Endocrinología, diabetes y metabolismo
  • Inmulogía y alergología
  • Bioquímica, genética y biología molecular (todo)

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