The essential role of chemokines in the selective regulation of lymphocyte homing

María Rosa Bono; Raúl Elgueta; Daniela Sauma; Karina Pino; Fabiola Osorio; Paula Michea; Alberto Fierro; Mario Rosemblatt

doi:10.1016/j.cytogfr.2007.01.004

The essential role of chemokines in the selective regulation of lymphocyte homing

María Rosa Bono, Raúl Elgueta, Daniela Sauma, Karina Pino, Fabiola Osorio, Paula Michea, Alberto Fierro, Mario Rosemblatt

Facultad de Ciencias de la Vida

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

46 Citas (Scopus)

Resumen

Knowledge of lymphocyte migration has become a major issue in our understanding of acquired immunity. The selective migration of naïve, effector, memory and regulatory T-cells is a multiple step process regulated by a specific arrangement of cytokines, chemokines and adhesion receptors that guide these cells to specific locations. Recent research has outlined two major pathways of lymphocyte trafficking under homeostatic and inflammatory conditions, one concerning tropism to cutaneous tissue and a second one related to mucosal-associated sites. In this article we will outline our present understanding of the role of cytokines and chemokines as regulators of lymphocyte migration through tissues.

Idioma original	Inglés
Páginas (desde-hasta)	33-43
Número de páginas	11
Publicación	Cytokine and Growth Factor Reviews
Volumen	18
N.º	1-2
DOI	https://doi.org/10.1016/j.cytogfr.2007.01.004
Estado	Publicada - feb. 2007

Áreas temáticas de ASJC Scopus

Endocrinología, diabetes y metabolismo
Inmulogía y alergología
Inmunología
Bioquímica, genética y biología molecular (todo)

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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10.1016/j.cytogfr.2007.01.004

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title = "The essential role of chemokines in the selective regulation of lymphocyte homing",

abstract = "Knowledge of lymphocyte migration has become a major issue in our understanding of acquired immunity. The selective migration of na{\"i}ve, effector, memory and regulatory T-cells is a multiple step process regulated by a specific arrangement of cytokines, chemokines and adhesion receptors that guide these cells to specific locations. Recent research has outlined two major pathways of lymphocyte trafficking under homeostatic and inflammatory conditions, one concerning tropism to cutaneous tissue and a second one related to mucosal-associated sites. In this article we will outline our present understanding of the role of cytokines and chemokines as regulators of lymphocyte migration through tissues.",

keywords = "Chemokines, Lymphocyte homing",

author = "Bono, {Mar{\'i}a Rosa} and Ra{\'u}l Elgueta and Daniela Sauma and Karina Pino and Fabiola Osorio and Paula Michea and Alberto Fierro and Mario Rosemblatt",

note = "Funding Information: We would like to thank Dr. Rodrigo Mora (Harvard Medical School) for valuable observations and suggestions. This article was supported in part by Conicyt grants to MRB (1060834), AF (1050023) and MR (1060253) and UNAB to MR. ",

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doi = "10.1016/j.cytogfr.2007.01.004",

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AU - Bono, María Rosa

AU - Elgueta, Raúl

AU - Sauma, Daniela

AU - Pino, Karina

AU - Osorio, Fabiola

AU - Michea, Paula

AU - Fierro, Alberto

AU - Rosemblatt, Mario

N1 - Funding Information: We would like to thank Dr. Rodrigo Mora (Harvard Medical School) for valuable observations and suggestions. This article was supported in part by Conicyt grants to MRB (1060834), AF (1050023) and MR (1060253) and UNAB to MR.

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N2 - Knowledge of lymphocyte migration has become a major issue in our understanding of acquired immunity. The selective migration of naïve, effector, memory and regulatory T-cells is a multiple step process regulated by a specific arrangement of cytokines, chemokines and adhesion receptors that guide these cells to specific locations. Recent research has outlined two major pathways of lymphocyte trafficking under homeostatic and inflammatory conditions, one concerning tropism to cutaneous tissue and a second one related to mucosal-associated sites. In this article we will outline our present understanding of the role of cytokines and chemokines as regulators of lymphocyte migration through tissues.

AB - Knowledge of lymphocyte migration has become a major issue in our understanding of acquired immunity. The selective migration of naïve, effector, memory and regulatory T-cells is a multiple step process regulated by a specific arrangement of cytokines, chemokines and adhesion receptors that guide these cells to specific locations. Recent research has outlined two major pathways of lymphocyte trafficking under homeostatic and inflammatory conditions, one concerning tropism to cutaneous tissue and a second one related to mucosal-associated sites. In this article we will outline our present understanding of the role of cytokines and chemokines as regulators of lymphocyte migration through tissues.

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The essential role of chemokines in the selective regulation of lymphocyte homing

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Áreas temáticas de ASJC Scopus

ODS de las Naciones Unidas

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