The emergence of neurotransmitters as immune modulators

Rafael Franco, Rodrigo Pacheco, Carmen Lluis, Gerard P. Ahern, Peta J. O'Connell

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

111 Citas (Scopus)


Initially, the idea that neurotransmitters could serve as immunomodulators emerged with the discovery that their release and diffusion from nervous tissue could lead to signaling through lymphocyte cell-surface receptors and the modulation of immune function. It is now evident that neurotransmitters can also be released from leukocytes and act as autocrine or paracrine modulators. Here, we review the data indicating that leukocytes synthesize and release 'neurotransmitters' and we also discuss the diverse effects that these compounds exert in a variety of immune cells. The role of neurotransmitters in immune-related diseases is also reviewed succinctly. Current and future developments in understanding the cross-talk between the immune and nervous systems will probably identify new avenues for treating immune-mediated diseases using agonists or antagonists of neurotransmitter receptors.

Idioma originalInglés
Páginas (desde-hasta)400-407
Número de páginas8
PublicaciónTrends in Immunology
EstadoPublicada - sep. 2007

Áreas temáticas de ASJC Scopus

  • Inmulogía y alergología
  • Inmunología


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