The effect of RU486 on transport, development and implantation of mouse embryos

L. S. Roblero, O. Fernández, H. B. Croxatto

Resultado de la investigación: Article

28 Citas (Scopus)

Resumen

Pregnancy was interrupted in Swiss-Rockefeller mice by a single subcutaneous injection of the antiprogesterone RU486 given postcoitally. A dose of 0.1 mg/animal injected on day 1, produced partial inhibition of pregnancy, a notable delay in embryonic development and a slight retention of embryos in the oviducts. When the same dose was injected on day 2, 3 or 4, no implantation sites were seen at autopsy performed on day 12 of pregnancy. Treatment with 0.5 or 1 mg/animal on day 1 produced the loss of a large proportion of the embryos from the genital tract by day 4 of pregnancy and suppressed implantation completely. These observations indicate that preimplantation phenomena in mice are highly dependent on progesterone action.

Idioma originalEnglish
Páginas (desde-hasta)549-555
Número de páginas7
PublicaciónContraception
Volumen36
N.º5
DOI
EstadoPublished - 1987

Huella dactilar

Pregnancy
Embryonic Structures
Oviducts
Subcutaneous Injections
Embryonic Development
Progesterone
Autopsy
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Citar esto

Roblero, L. S. ; Fernández, O. ; Croxatto, H. B. / The effect of RU486 on transport, development and implantation of mouse embryos. En: Contraception. 1987 ; Vol. 36, N.º 5. pp. 549-555.
@article{ba4dc55ed91a4db2ae49352af9c9ca36,
title = "The effect of RU486 on transport, development and implantation of mouse embryos",
abstract = "Pregnancy was interrupted in Swiss-Rockefeller mice by a single subcutaneous injection of the antiprogesterone RU486 given postcoitally. A dose of 0.1 mg/animal injected on day 1, produced partial inhibition of pregnancy, a notable delay in embryonic development and a slight retention of embryos in the oviducts. When the same dose was injected on day 2, 3 or 4, no implantation sites were seen at autopsy performed on day 12 of pregnancy. Treatment with 0.5 or 1 mg/animal on day 1 produced the loss of a large proportion of the embryos from the genital tract by day 4 of pregnancy and suppressed implantation completely. These observations indicate that preimplantation phenomena in mice are highly dependent on progesterone action.",
author = "Roblero, {L. S.} and O. Fern{\'a}ndez and Croxatto, {H. B.}",
year = "1987",
doi = "10.1016/0010-7824(87)90007-2",
language = "English",
volume = "36",
pages = "549--555",
journal = "Contraception",
issn = "0010-7824",
publisher = "Elsevier USA",
number = "5",

}

The effect of RU486 on transport, development and implantation of mouse embryos. / Roblero, L. S.; Fernández, O.; Croxatto, H. B.

En: Contraception, Vol. 36, N.º 5, 1987, p. 549-555.

Resultado de la investigación: Article

TY - JOUR

T1 - The effect of RU486 on transport, development and implantation of mouse embryos

AU - Roblero, L. S.

AU - Fernández, O.

AU - Croxatto, H. B.

PY - 1987

Y1 - 1987

N2 - Pregnancy was interrupted in Swiss-Rockefeller mice by a single subcutaneous injection of the antiprogesterone RU486 given postcoitally. A dose of 0.1 mg/animal injected on day 1, produced partial inhibition of pregnancy, a notable delay in embryonic development and a slight retention of embryos in the oviducts. When the same dose was injected on day 2, 3 or 4, no implantation sites were seen at autopsy performed on day 12 of pregnancy. Treatment with 0.5 or 1 mg/animal on day 1 produced the loss of a large proportion of the embryos from the genital tract by day 4 of pregnancy and suppressed implantation completely. These observations indicate that preimplantation phenomena in mice are highly dependent on progesterone action.

AB - Pregnancy was interrupted in Swiss-Rockefeller mice by a single subcutaneous injection of the antiprogesterone RU486 given postcoitally. A dose of 0.1 mg/animal injected on day 1, produced partial inhibition of pregnancy, a notable delay in embryonic development and a slight retention of embryos in the oviducts. When the same dose was injected on day 2, 3 or 4, no implantation sites were seen at autopsy performed on day 12 of pregnancy. Treatment with 0.5 or 1 mg/animal on day 1 produced the loss of a large proportion of the embryos from the genital tract by day 4 of pregnancy and suppressed implantation completely. These observations indicate that preimplantation phenomena in mice are highly dependent on progesterone action.

UR - http://www.scopus.com/inward/record.url?scp=0023576139&partnerID=8YFLogxK

U2 - 10.1016/0010-7824(87)90007-2

DO - 10.1016/0010-7824(87)90007-2

M3 - Article

C2 - 3447816

AN - SCOPUS:0023576139

VL - 36

SP - 549

EP - 555

JO - Contraception

JF - Contraception

SN - 0010-7824

IS - 5

ER -