The dynamic organization of gene-regulatory machinery in nuclear microenvironments

Sayyed K. Zaidi, Daniel W. Young, Je Yong Choi, Jitesh Pratap, Amjad Javed, Martin Montecino, Janet L. Stein, Andre J. van Wijnen, Jane B. Lian, Gary S. Stein

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

97 Citas (Scopus)


Nuclear components are functionally linked with the dynamic temporal and spatial compartmentalization, sorting and integration of regulatory information to facilitate its selective use. For example, the subnuclear targeting of transcription factors to punctate sites in the interphase nucleus mechanistically couples chromatin remodelling and the execution of signalling cascades that mediate gene expression with the combinatorial assembly of the regulatory machinery for biological control. In addition, a mitotic cycle of selective partitioning and sequential restoration of the transcriptional machinery provides a basis for the reassembly of regulatory complexes to render progeny cells competent for phenotypic gene expression. When this intranuclear targeting and localization of regulatory proteins is compromised, diseases, such as cancer, can occur. A detailed understanding of this process will provide further options for diagnosis and treatment.

Idioma originalInglés
Páginas (desde-hasta)128-133
Número de páginas6
PublicaciónEMBO Reports
EstadoPublicada - 2005

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Biología molecular
  • Genética


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