The clock keeps on ticking: Emerging roles for circadian regulation in the control of fungal physiology and pathogenesis

Luis F. Larrondo, Paulo Canessa

Resultado de la investigación: Chapter

2 Citas (Scopus)

Resumen

Tic-tac, tic-tac, the sound of time is familiar to us, yet, it also silently shapes daily biological processes conferring 24-hour rhythms in, among others, cellular and systemic signaling, gene expression, and metabolism. Indeed, circadian clocks are molecular machines that permit temporal control of a variety of processes in individuals, with a close to 24-hour period, optimizing cellular dynamics in synchrony with daily environmental cycles. For over three decades, the molecular bases of these clocks have been extensively described in the filamentous fungus Neurospora crassa, yet, there have been few molecular studies in fungi other than Neurospora, despite evidence of rhythmic phenomena in many fungal species, including pathogenic ones. This chapter will revise the mechanisms underlying clock regulation in the model fungus N. crassa, as well as recent findings obtained in several fungi. In particular, this chapter will review the effect of circadian regulation of virulence and organismal interactions, focusing on the phytopathogen Botrytis cinerea, as well as several entomopathogenic fungi, including the behavior-manipulating species Ophiocordyceps kimflemingiae and Entomophthora muscae. Finally, this review will comment current efforts in the study of mammalian pathogenic fungi, while highlighting recent circadian lessons from parasites such as Trypanosoma and Plasmodium. The clock keeps on ticking, whether we can hear it or not.

Idioma originalEnglish
Título de la publicación alojadaCurrent Topics in Microbiology and Immunology
EditorialSpringer Verlag
Páginas121-156
Número de páginas36
DOI
EstadoPublished - 1 ene 2019

Serie de la publicación

NombreCurrent Topics in Microbiology and Immunology
Volumen422
ISSN (versión impresa)0070-217X
ISSN (versión digital)2196-9965

Huella dactilar

Fungi
Tics
Neurospora crassa
Entomophthora
Neurospora
Botrytis
Trypanosoma
Biological Phenomena
Circadian Clocks
Plasmodium
Virulence
Parasites
Gene Expression

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

Citar esto

Larrondo, L. F., & Canessa, P. (2019). The clock keeps on ticking: Emerging roles for circadian regulation in the control of fungal physiology and pathogenesis. En Current Topics in Microbiology and Immunology (pp. 121-156). (Current Topics in Microbiology and Immunology; Vol. 422). Springer Verlag. https://doi.org/10.1007/82_2018_143
Larrondo, Luis F. ; Canessa, Paulo. / The clock keeps on ticking : Emerging roles for circadian regulation in the control of fungal physiology and pathogenesis. Current Topics in Microbiology and Immunology. Springer Verlag, 2019. pp. 121-156 (Current Topics in Microbiology and Immunology).
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Larrondo, LF & Canessa, P 2019, The clock keeps on ticking: Emerging roles for circadian regulation in the control of fungal physiology and pathogenesis. En Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol. 422, Springer Verlag, pp. 121-156. https://doi.org/10.1007/82_2018_143

The clock keeps on ticking : Emerging roles for circadian regulation in the control of fungal physiology and pathogenesis. / Larrondo, Luis F.; Canessa, Paulo.

Current Topics in Microbiology and Immunology. Springer Verlag, 2019. p. 121-156 (Current Topics in Microbiology and Immunology; Vol. 422).

Resultado de la investigación: Chapter

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Larrondo LF, Canessa P. The clock keeps on ticking: Emerging roles for circadian regulation in the control of fungal physiology and pathogenesis. En Current Topics in Microbiology and Immunology. Springer Verlag. 2019. p. 121-156. (Current Topics in Microbiology and Immunology). https://doi.org/10.1007/82_2018_143