The characterization of anti-T. cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ROS release

César Echeverría, Valentina Romero, Rodrigo Arancibia, Hugo Klahn, Ignacio Montorfano, Ricardo Armisen, Vincenzo Borgna, Felipe Simon, Rodrigo Ramirez-Tagle

Resultado de la investigación: Contribución a una revistaArtículo

7 Citas (Scopus)

Resumen

Trypanosoma cruzi (T. cruzi) is the parasite that causes Chagas disease. Nifurtimox is the most used drug against the T. cruzi, this drug increases intermediaries nitro group, being mainly responsible for the high toxicity component, for this reason it is important to study new organic compounds and thus improve therapeutic strategies against Chagas disease. The electronic effects of ferrocenyl and cyrhetrenyl fragments were investigated by DFT calculation. A close correlation was found between HOMO–LUMO gap of nitro radical NO2 with the experimental reduction potential found for nitro group and IC50 of two forms the T. cruzi (epimastigote and trypomastigote). The IC50 on human hepatoma cells is higher for both compounds compared to IC50 demonstrated in the two forms the T. cruzi, and additionally show reactive oxygen species release. The information obtained in this paper could generate two new drugs with anti-T. cruzi activity, but additional studies are needed.

Idioma originalInglés
Páginas (desde-hasta)743-749
Número de páginas7
PublicaciónBioMetals
Volumen29
N.º4
DOI
EstadoPublicada - 1 ago 2016

Áreas temáticas de ASJC Scopus

  • Biomateriales
  • Bioquímica, genética y biología molecular (todo)
  • Agricultura y biología (todo)
  • Metales y aleaciones

Huella Profundice en los temas de investigación de 'The characterization of anti-T. cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ROS release'. En conjunto forman una huella única.

  • Citar esto

    Echeverría, C., Romero, V., Arancibia, R., Klahn, H., Montorfano, I., Armisen, R., Borgna, V., Simon, F., & Ramirez-Tagle, R. (2016). The characterization of anti-T. cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ROS release. BioMetals, 29(4), 743-749. https://doi.org/10.1007/s10534-016-9953-1