The characterization of anti-T. cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ROS release

César Echeverría, Valentina Romero, Rodrigo Arancibia, Hugo Klahn, Ignacio Montorfano, Ricardo Armisen, Vincenzo Borgna, Felipe Simon, Rodrigo Ramirez-Tagle

Resultado de la investigación: Article

6 Citas (Scopus)

Resumen

Trypanosoma cruzi (T. cruzi) is the parasite that causes Chagas disease. Nifurtimox is the most used drug against the T. cruzi, this drug increases intermediaries nitro group, being mainly responsible for the high toxicity component, for this reason it is important to study new organic compounds and thus improve therapeutic strategies against Chagas disease. The electronic effects of ferrocenyl and cyrhetrenyl fragments were investigated by DFT calculation. A close correlation was found between HOMO–LUMO gap of nitro radical NO2 with the experimental reduction potential found for nitro group and IC50 of two forms the T. cruzi (epimastigote and trypomastigote). The IC50 on human hepatoma cells is higher for both compounds compared to IC50 demonstrated in the two forms the T. cruzi, and additionally show reactive oxygen species release. The information obtained in this paper could generate two new drugs with anti-T. cruzi activity, but additional studies are needed.

Idioma originalEnglish
Páginas (desde-hasta)743-749
Número de páginas7
PublicaciónBioMetals
Volumen29
N.º4
DOI
EstadoPublished - 1 ago 2016

Huella dactilar

Trypanosoma cruzi
Inhibitory Concentration 50
inhibitory concentration 50
Nifurtimox
Organic compounds
Chagas disease
Discrete Fourier transforms
Pharmaceutical Preparations
Chagas Disease
Toxicity
Oxygen
Reactive Oxygen Species
epimastigotes
trypomastigotes
drugs
new drugs
hepatoma
organic compounds
electronics
reactive oxygen species

ASJC Scopus subject areas

  • Biomaterials
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Metals and Alloys

Citar esto

Echeverría, C., Romero, V., Arancibia, R., Klahn, H., Montorfano, I., Armisen, R., ... Ramirez-Tagle, R. (2016). The characterization of anti-T. cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ROS release. BioMetals, 29(4), 743-749. https://doi.org/10.1007/s10534-016-9953-1
Echeverría, César ; Romero, Valentina ; Arancibia, Rodrigo ; Klahn, Hugo ; Montorfano, Ignacio ; Armisen, Ricardo ; Borgna, Vincenzo ; Simon, Felipe ; Ramirez-Tagle, Rodrigo. / The characterization of anti-T. cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ROS release. En: BioMetals. 2016 ; Vol. 29, N.º 4. pp. 743-749.
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abstract = "Trypanosoma cruzi (T. cruzi) is the parasite that causes Chagas disease. Nifurtimox is the most used drug against the T. cruzi, this drug increases intermediaries nitro group, being mainly responsible for the high toxicity component, for this reason it is important to study new organic compounds and thus improve therapeutic strategies against Chagas disease. The electronic effects of ferrocenyl and cyrhetrenyl fragments were investigated by DFT calculation. A close correlation was found between HOMO–LUMO gap of nitro radical NO2 − with the experimental reduction potential found for nitro group and IC50 of two forms the T. cruzi (epimastigote and trypomastigote). The IC50 on human hepatoma cells is higher for both compounds compared to IC50 demonstrated in the two forms the T. cruzi, and additionally show reactive oxygen species release. The information obtained in this paper could generate two new drugs with anti-T. cruzi activity, but additional studies are needed.",
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Echeverría, C, Romero, V, Arancibia, R, Klahn, H, Montorfano, I, Armisen, R, Borgna, V, Simon, F & Ramirez-Tagle, R 2016, 'The characterization of anti-T. cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ROS release', BioMetals, vol. 29, n.º 4, pp. 743-749. https://doi.org/10.1007/s10534-016-9953-1

The characterization of anti-T. cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ROS release. / Echeverría, César; Romero, Valentina; Arancibia, Rodrigo; Klahn, Hugo; Montorfano, Ignacio; Armisen, Ricardo; Borgna, Vincenzo; Simon, Felipe; Ramirez-Tagle, Rodrigo.

En: BioMetals, Vol. 29, N.º 4, 01.08.2016, p. 743-749.

Resultado de la investigación: Article

TY - JOUR

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AU - Echeverría, César

AU - Romero, Valentina

AU - Arancibia, Rodrigo

AU - Klahn, Hugo

AU - Montorfano, Ignacio

AU - Armisen, Ricardo

AU - Borgna, Vincenzo

AU - Simon, Felipe

AU - Ramirez-Tagle, Rodrigo

PY - 2016/8/1

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N2 - Trypanosoma cruzi (T. cruzi) is the parasite that causes Chagas disease. Nifurtimox is the most used drug against the T. cruzi, this drug increases intermediaries nitro group, being mainly responsible for the high toxicity component, for this reason it is important to study new organic compounds and thus improve therapeutic strategies against Chagas disease. The electronic effects of ferrocenyl and cyrhetrenyl fragments were investigated by DFT calculation. A close correlation was found between HOMO–LUMO gap of nitro radical NO2 − with the experimental reduction potential found for nitro group and IC50 of two forms the T. cruzi (epimastigote and trypomastigote). The IC50 on human hepatoma cells is higher for both compounds compared to IC50 demonstrated in the two forms the T. cruzi, and additionally show reactive oxygen species release. The information obtained in this paper could generate two new drugs with anti-T. cruzi activity, but additional studies are needed.

AB - Trypanosoma cruzi (T. cruzi) is the parasite that causes Chagas disease. Nifurtimox is the most used drug against the T. cruzi, this drug increases intermediaries nitro group, being mainly responsible for the high toxicity component, for this reason it is important to study new organic compounds and thus improve therapeutic strategies against Chagas disease. The electronic effects of ferrocenyl and cyrhetrenyl fragments were investigated by DFT calculation. A close correlation was found between HOMO–LUMO gap of nitro radical NO2 − with the experimental reduction potential found for nitro group and IC50 of two forms the T. cruzi (epimastigote and trypomastigote). The IC50 on human hepatoma cells is higher for both compounds compared to IC50 demonstrated in the two forms the T. cruzi, and additionally show reactive oxygen species release. The information obtained in this paper could generate two new drugs with anti-T. cruzi activity, but additional studies are needed.

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