The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells is host specific

Susan M. Bueno, Pablo A. González, Leandro J. Carreño, Jaime A. Tobar, Guido C. Mora, Cristian J. Pereda, Flavio Salazar-Onfray, Alexis M. Kalergis

Resultado de la investigación: Article

49 Citas (Scopus)

Resumen

Infection with Salmonella enterica serovar Typhimurium (S. Typhimurium) causes a severe and lethal systemic disease in mice, characterized by poor activation of the adaptive immune response against Salmonella-derived antigens. Recently, we and others have reported that this feature relies on the ability of S. Typhimurium to survive within murine dendritic cells (DCs) and avoid the presentation of bacteria-derived antigens to T cells. In contrast, here we show that infection of murine DCs with either S. Typhi or S. Enteritidis, two serovars adapted to different hosts, leads to an efficient T-cell activation both in vitro and in vivo. Accordingly, S. Typhi and S. Enteritidis failed to replicate within murine DCs and were quickly degraded, allowing T-cell activation. In contrast, human DCs were found to be permissive for survival and proliferation of S. Typhi, but not for S. Typhimurium or S. Enteritidis. Our data suggest that Salmonella host restriction is characterized by the ability of these bacteria to survive within DCs and avoid activation of the adaptive immune response in their specific hosts.

Idioma originalEnglish
Páginas (desde-hasta)522-533
Número de páginas12
PublicaciónImmunology
Volumen124
N.º4
DOI
EstadoPublished - 1 ago 2008

Huella dactilar

Antigen Presentation
Salmonella
Dendritic Cells
T-Lymphocytes
Adaptive Immunity
Bacteria
Antigens
Salmonella enterica
Infection
Survival
Serogroup

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Citar esto

Bueno, S. M., González, P. A., Carreño, L. J., Tobar, J. A., Mora, G. C., Pereda, C. J., ... Kalergis, A. M. (2008). The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells is host specific. Immunology, 124(4), 522-533. https://doi.org/10.1111/j.1365-2567.2008.02805.x
Bueno, Susan M. ; González, Pablo A. ; Carreño, Leandro J. ; Tobar, Jaime A. ; Mora, Guido C. ; Pereda, Cristian J. ; Salazar-Onfray, Flavio ; Kalergis, Alexis M. / The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells is host specific. En: Immunology. 2008 ; Vol. 124, N.º 4. pp. 522-533.
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abstract = "Infection with Salmonella enterica serovar Typhimurium (S. Typhimurium) causes a severe and lethal systemic disease in mice, characterized by poor activation of the adaptive immune response against Salmonella-derived antigens. Recently, we and others have reported that this feature relies on the ability of S. Typhimurium to survive within murine dendritic cells (DCs) and avoid the presentation of bacteria-derived antigens to T cells. In contrast, here we show that infection of murine DCs with either S. Typhi or S. Enteritidis, two serovars adapted to different hosts, leads to an efficient T-cell activation both in vitro and in vivo. Accordingly, S. Typhi and S. Enteritidis failed to replicate within murine DCs and were quickly degraded, allowing T-cell activation. In contrast, human DCs were found to be permissive for survival and proliferation of S. Typhi, but not for S. Typhimurium or S. Enteritidis. Our data suggest that Salmonella host restriction is characterized by the ability of these bacteria to survive within DCs and avoid activation of the adaptive immune response in their specific hosts.",
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Bueno, SM, González, PA, Carreño, LJ, Tobar, JA, Mora, GC, Pereda, CJ, Salazar-Onfray, F & Kalergis, AM 2008, 'The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells is host specific', Immunology, vol. 124, n.º 4, pp. 522-533. https://doi.org/10.1111/j.1365-2567.2008.02805.x

The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells is host specific. / Bueno, Susan M.; González, Pablo A.; Carreño, Leandro J.; Tobar, Jaime A.; Mora, Guido C.; Pereda, Cristian J.; Salazar-Onfray, Flavio; Kalergis, Alexis M.

En: Immunology, Vol. 124, N.º 4, 01.08.2008, p. 522-533.

Resultado de la investigación: Article

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T1 - The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells is host specific

AU - Bueno, Susan M.

AU - González, Pablo A.

AU - Carreño, Leandro J.

AU - Tobar, Jaime A.

AU - Mora, Guido C.

AU - Pereda, Cristian J.

AU - Salazar-Onfray, Flavio

AU - Kalergis, Alexis M.

PY - 2008/8/1

Y1 - 2008/8/1

N2 - Infection with Salmonella enterica serovar Typhimurium (S. Typhimurium) causes a severe and lethal systemic disease in mice, characterized by poor activation of the adaptive immune response against Salmonella-derived antigens. Recently, we and others have reported that this feature relies on the ability of S. Typhimurium to survive within murine dendritic cells (DCs) and avoid the presentation of bacteria-derived antigens to T cells. In contrast, here we show that infection of murine DCs with either S. Typhi or S. Enteritidis, two serovars adapted to different hosts, leads to an efficient T-cell activation both in vitro and in vivo. Accordingly, S. Typhi and S. Enteritidis failed to replicate within murine DCs and were quickly degraded, allowing T-cell activation. In contrast, human DCs were found to be permissive for survival and proliferation of S. Typhi, but not for S. Typhimurium or S. Enteritidis. Our data suggest that Salmonella host restriction is characterized by the ability of these bacteria to survive within DCs and avoid activation of the adaptive immune response in their specific hosts.

AB - Infection with Salmonella enterica serovar Typhimurium (S. Typhimurium) causes a severe and lethal systemic disease in mice, characterized by poor activation of the adaptive immune response against Salmonella-derived antigens. Recently, we and others have reported that this feature relies on the ability of S. Typhimurium to survive within murine dendritic cells (DCs) and avoid the presentation of bacteria-derived antigens to T cells. In contrast, here we show that infection of murine DCs with either S. Typhi or S. Enteritidis, two serovars adapted to different hosts, leads to an efficient T-cell activation both in vitro and in vivo. Accordingly, S. Typhi and S. Enteritidis failed to replicate within murine DCs and were quickly degraded, allowing T-cell activation. In contrast, human DCs were found to be permissive for survival and proliferation of S. Typhi, but not for S. Typhimurium or S. Enteritidis. Our data suggest that Salmonella host restriction is characterized by the ability of these bacteria to survive within DCs and avoid activation of the adaptive immune response in their specific hosts.

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KW - Salmonella

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