The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium

Coral Pardo-Esté, Alejandro A. Hidalgo, Camila Aguirre, Alan C. Briones, Carolina E. Cabezas, Juan Castro-Severyn, Juan A. Fuentes, Cecilia M. Opazo, Claudia A. Riedel, Carolina Otero, Rodrigo Pacheco, Miguel A. Valvano, Claudia P. Saavedra

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

14 Citas (Scopus)

Resumen

Salmonella enterica Serovar Typhimurium (S. Typhimurium) is an intracellular bacterium that overcomes host immune system barriers for successful infection. The bacterium colonizes the proximal small intestine, penetrates the epithelial layer, and is engulfed by macrophages and neutrophils. Intracellularly, S. Typhimurium encounters highly toxic reactive oxygen species including hydrogen peroxide and hypochlorous acid. The molecular mechanisms of Salmonella resistance to intracellular oxidative stress is not completely understood. The ArcAB two-component system is a global regulatory system that responds to oxygen. In this work, we show that the ArcA response regulator participates in Salmonella adaptation to changing oxygen levels and is also involved in promoting intracellular survival in macrophages and neutrophils, enabling S. Typhimurium to successfully establish a systemic infection.

Idioma originalInglés
Número de artículoe0203497
PublicaciónPLoS ONE
Volumen13
N.º9
DOI
EstadoPublicada - 4 sep 2018

Áreas temáticas de ASJC Scopus

  • Bioquímica, genética y biología molecular (todo)
  • Agricultura y biología (todo)

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