The Andes hantavirus NSs protein is expressed from the viral small mRNA by a leaky scanning mechanism

Jorge Vera-Otarola, Loretto Solis, Ricardo Soto-Rifo, Emiliano P. Ricci, Karla Pino, Nicole D. Tischler, Théophile Ohlmann, Jean Luc Darlix, Marcelo López-Lastra

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

40 Citas (Scopus)

Resumen

The small mRNA (SmRNA) of all Bunyaviridae encodes the nucleocapsid (N) protein. In 4 out of 5 genera in the Bunyaviridae, the smRNA encodes an additional nonstructural protein denominated NSs. In this study, we show that Andes hantavirus (ANDV) SmRNA encodes an NSs protein. Data show that the NSs protein is expressed in the context of an ANDV infection. Additionally, our results suggest that translation initiation from the NSs initiation codon is mediated by ribosomal subunits that have bypassed the upstream N protein initiation codon through a leaky scanning mechanism.

Idioma originalInglés
Páginas (desde-hasta)2176-2187
Número de páginas12
PublicaciónJournal of Virology
Volumen86
N.º4
DOI
EstadoPublicada - feb 2012

Áreas temáticas de ASJC Scopus

  • Microbiología
  • Inmunología
  • Insectos
  • Virología

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