The analgesic effect of clonixine is not mediated by 5-HT3 subtype receptors

C. Paeile, S. E. Bustamante, F. Sierralta, D. Bustamante, H. F. Miranda

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

1. 1. The analgesic effect of clonixinate of L-lysine (Clx) in the nociceptive C-fiber reflex in rat and in the writhing test in mice is reported. 2. 2. Clx was administered by three routes, i.v., i.t. and i.c.v., inducing a dose-dependent antinociception. 3. 3. The antinociceptive effect of Clx was 40-45% with respect to the control integration values in the nociceptive C-fiber reflex method. 4. 4. The writhing test yielded ED50 values (mg/kg) of 12.0 ± 1.3 (i.p.), 1.8 ± 0.2 (i.t.) and 0.9 ± 0.1 (i.c.v.) for Clx administration. 5. 5. Ondansetron was not able to antagonize the antinociception response of Clx in the algesiometric tests used. 6. 6. Chlorophenilbiguanide did not produce any significative change in the analgesic effect of Clx in the nociceptive C-fiber reflex method. 7. 7. It is suggested that the mechanism of action of the central analgesia of Clx is not mediated by 5-HT3 subtype receptors.

Idioma originalInglés
Páginas (desde-hasta)1369-1374
Número de páginas6
PublicaciónGeneral Pharmacology
Volumen26
N.º6
DOI
EstadoPublicada - 1 ene 1995

Áreas temáticas de ASJC Scopus

  • Farmacología

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