Tgf-ß alterations in oral squamous cell carcinoma

Jorge Candia, Carolina Somarriva, Diego Fonseca, Fernando Parada, Jorge Briceño, Alejandra Fernández

Resultado de la investigación: Review article

Resumen

The transforming growth factor beta (TGF-ß) is a cytokine that plays crucial roles in the regulation of angiogenesis, immune response, proliferation, migration and apoptosis of cells. In addition, it can inhibit cell progression and stimulate apoptosis in early stages of cancer. TGF-ß is a multifunctional homodimeric protein secreted by various cell lines, which have three different isoforms: TGF-ß1, TGF-ß2 and TGF-ß3. In normal conditions, TGF-ß1 activates some tumor suppressor cell signaling pathways that inhibit proliferation and are involved in cell migration, differentiation and apoptosis. However, in more advanced stages of cancer, when TGF-ß1 is altered, it acts as a promoter of tumorigenesis and may cause: 1) increased TGF-ß1, 2) overexpression of TGF-ß1 receptors (TßR), 3) TßR mutations, and 4) downregulation of TGF-beta receptor. In oral squamous cell carcinoma, the path is altered especially at the level of transmembrane receptors, with the TßR-II and TßR-III subtypes being the most affected. However, there is little information on the prognostic role it plays in the various types of cancers. It is important to study the signaling pathways of TGF-ß in order to develop techniques that may help detect their alterations and restore their normal operation. The objective of this review is to describe the alterations of TGF-ß in oral squamous cell carcinoma.

Idioma originalEnglish
Páginas (desde-hasta)207-214
Número de páginas8
PublicaciónJournal of Oral Research
Volumen5
N.º5
DOI
EstadoPublished - 2016

Huella dactilar

Transforming Growth Factor beta
Squamous Cell Carcinoma
Apoptosis
Cell Movement
Neoplasms
Cell Differentiation
Protein Isoforms
Carcinogenesis
Down-Regulation
Cytokines
Cell Line
Mutation

ASJC Scopus subject areas

  • Dentistry(all)

Citar esto

Candia, J., Somarriva, C., Fonseca, D., Parada, F., Briceño, J., & Fernández, A. (2016). Tgf-ß alterations in oral squamous cell carcinoma. Journal of Oral Research, 5(5), 207-214. https://doi.org/10.17126/joralres.2016.045
Candia, Jorge ; Somarriva, Carolina ; Fonseca, Diego ; Parada, Fernando ; Briceño, Jorge ; Fernández, Alejandra. / Tgf-ß alterations in oral squamous cell carcinoma. En: Journal of Oral Research. 2016 ; Vol. 5, N.º 5. pp. 207-214.
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title = "Tgf-{\ss} alterations in oral squamous cell carcinoma",
abstract = "The transforming growth factor beta (TGF-{\ss}) is a cytokine that plays crucial roles in the regulation of angiogenesis, immune response, proliferation, migration and apoptosis of cells. In addition, it can inhibit cell progression and stimulate apoptosis in early stages of cancer. TGF-{\ss} is a multifunctional homodimeric protein secreted by various cell lines, which have three different isoforms: TGF-{\ss}1, TGF-{\ss}2 and TGF-{\ss}3. In normal conditions, TGF-{\ss}1 activates some tumor suppressor cell signaling pathways that inhibit proliferation and are involved in cell migration, differentiation and apoptosis. However, in more advanced stages of cancer, when TGF-{\ss}1 is altered, it acts as a promoter of tumorigenesis and may cause: 1) increased TGF-{\ss}1, 2) overexpression of TGF-{\ss}1 receptors (T{\ss}R), 3) T{\ss}R mutations, and 4) downregulation of TGF-beta receptor. In oral squamous cell carcinoma, the path is altered especially at the level of transmembrane receptors, with the T{\ss}R-II and T{\ss}R-III subtypes being the most affected. However, there is little information on the prognostic role it plays in the various types of cancers. It is important to study the signaling pathways of TGF-{\ss} in order to develop techniques that may help detect their alterations and restore their normal operation. The objective of this review is to describe the alterations of TGF-{\ss} in oral squamous cell carcinoma.",
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Candia, J, Somarriva, C, Fonseca, D, Parada, F, Briceño, J & Fernández, A 2016, 'Tgf-ß alterations in oral squamous cell carcinoma', Journal of Oral Research, vol. 5, n.º 5, pp. 207-214. https://doi.org/10.17126/joralres.2016.045

Tgf-ß alterations in oral squamous cell carcinoma. / Candia, Jorge; Somarriva, Carolina; Fonseca, Diego; Parada, Fernando; Briceño, Jorge; Fernández, Alejandra.

En: Journal of Oral Research, Vol. 5, N.º 5, 2016, p. 207-214.

Resultado de la investigación: Review article

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T1 - Tgf-ß alterations in oral squamous cell carcinoma

AU - Candia, Jorge

AU - Somarriva, Carolina

AU - Fonseca, Diego

AU - Parada, Fernando

AU - Briceño, Jorge

AU - Fernández, Alejandra

PY - 2016

Y1 - 2016

N2 - The transforming growth factor beta (TGF-ß) is a cytokine that plays crucial roles in the regulation of angiogenesis, immune response, proliferation, migration and apoptosis of cells. In addition, it can inhibit cell progression and stimulate apoptosis in early stages of cancer. TGF-ß is a multifunctional homodimeric protein secreted by various cell lines, which have three different isoforms: TGF-ß1, TGF-ß2 and TGF-ß3. In normal conditions, TGF-ß1 activates some tumor suppressor cell signaling pathways that inhibit proliferation and are involved in cell migration, differentiation and apoptosis. However, in more advanced stages of cancer, when TGF-ß1 is altered, it acts as a promoter of tumorigenesis and may cause: 1) increased TGF-ß1, 2) overexpression of TGF-ß1 receptors (TßR), 3) TßR mutations, and 4) downregulation of TGF-beta receptor. In oral squamous cell carcinoma, the path is altered especially at the level of transmembrane receptors, with the TßR-II and TßR-III subtypes being the most affected. However, there is little information on the prognostic role it plays in the various types of cancers. It is important to study the signaling pathways of TGF-ß in order to develop techniques that may help detect their alterations and restore their normal operation. The objective of this review is to describe the alterations of TGF-ß in oral squamous cell carcinoma.

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KW - Smad4 protein

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