Testosterone and tolerance in rat vas deferens

H. F. Miranda; W. W. Wolstenholme

doi:10.1016/0306-3623(84)90210-6

Testosterone and tolerance in rat vas deferens

H. F. Miranda, W. W. Wolstenholme

Facultad Medicina

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1. 1. Testosterone is able to inhibit the development of tolerance in the smooth muscle of the rat vas deferens. 2. 2. Cycloheximide and actinomycin D also inhibit the tolerance to morphine and ethanol in smooth muscle of rat vas deferens. 3. 3. The toxic effect of cycloheximide and actinomycin D do not play roles in the inhibition of tolerance. 4. 4. The physiological responses of vas deferens to norepinephrine are not altered by cycloheximide and actinomycin D.

Idioma original	Inglés
Páginas (desde-hasta)	529-533
Número de páginas	5
Publicación	General Pharmacology
Volumen	15
N.º	6
DOI	https://doi.org/10.1016/0306-3623(84)90210-6
Estado	Publicada - 1984

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Farmacología

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10.1016/0306-3623(84)90210-6

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title = "Testosterone and tolerance in rat vas deferens",

abstract = "1. 1. Testosterone is able to inhibit the development of tolerance in the smooth muscle of the rat vas deferens. 2. 2. Cycloheximide and actinomycin D also inhibit the tolerance to morphine and ethanol in smooth muscle of rat vas deferens. 3. 3. The toxic effect of cycloheximide and actinomycin D do not play roles in the inhibition of tolerance. 4. 4. The physiological responses of vas deferens to norepinephrine are not altered by cycloheximide and actinomycin D.",

author = "Miranda, {H. F.} and Wolstenholme, {W. W.}",

year = "1984",

doi = "10.1016/0306-3623(84)90210-6",

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AU - Wolstenholme, W. W.

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N2 - 1. 1. Testosterone is able to inhibit the development of tolerance in the smooth muscle of the rat vas deferens. 2. 2. Cycloheximide and actinomycin D also inhibit the tolerance to morphine and ethanol in smooth muscle of rat vas deferens. 3. 3. The toxic effect of cycloheximide and actinomycin D do not play roles in the inhibition of tolerance. 4. 4. The physiological responses of vas deferens to norepinephrine are not altered by cycloheximide and actinomycin D.

AB - 1. 1. Testosterone is able to inhibit the development of tolerance in the smooth muscle of the rat vas deferens. 2. 2. Cycloheximide and actinomycin D also inhibit the tolerance to morphine and ethanol in smooth muscle of rat vas deferens. 3. 3. The toxic effect of cycloheximide and actinomycin D do not play roles in the inhibition of tolerance. 4. 4. The physiological responses of vas deferens to norepinephrine are not altered by cycloheximide and actinomycin D.

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U2 - 10.1016/0306-3623(84)90210-6

DO - 10.1016/0306-3623(84)90210-6

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AN - SCOPUS:0021701907

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VL - 15

SP - 529

EP - 533

JO - General Pharmacology

JF - General Pharmacology

IS - 6

ER -

Testosterone and tolerance in rat vas deferens

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