Terapia de reemplazo con testosterona y cáncer de próstata: ¿la caída de un paradigma?

Octavio A. Castillo, Gastón López-Fontana, Ivar Vidal-Mora, José Daniel López Laur

Resultado de la investigación: Review article

Resumen

For six decades, it has been a part of the conventional medical wisdom that higher levels of testosterone increase the risk of prostate cancer. This belief is mostly derived from the well-documented regression of prostate cancer after surgical or pharmacological castration. However, there is an absence of scientific data supporting the concept that higher testosterone levels are associated with an increased risk of prostate cancer. Moreover, men with hypogonadism have substantial rates of prostate cancer in prostatic biopsies, suggesting that low testosterone has no protective effect against the development of prostate cancer. Moreover, prostate cancer rate is higher in elderly patients when hormonal levels are low. These results argue against an increased risk of prostate cancer with testosterone replacement therapy.

Idioma originalSpanish
Páginas (desde-hasta)e6115
PublicaciónMedwave
Volumen15
N.º3
DOI
EstadoPublished - 6 abr 2015
Publicado de forma externa

Huella dactilar

Testosterone
Prostatic Neoplasms
Therapeutics
Hypogonadism
Castration
Pharmacology
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Citar esto

Castillo, O. A., López-Fontana, G., Vidal-Mora, I., & López Laur, J. D. (2015). Terapia de reemplazo con testosterona y cáncer de próstata: ¿la caída de un paradigma? Medwave, 15(3), e6115. https://doi.org/10.5867/medwave.2015.03.6115
Castillo, Octavio A. ; López-Fontana, Gastón ; Vidal-Mora, Ivar ; López Laur, José Daniel. / Terapia de reemplazo con testosterona y cáncer de próstata : ¿la caída de un paradigma?. En: Medwave. 2015 ; Vol. 15, N.º 3. pp. e6115.
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abstract = "For six decades, it has been a part of the conventional medical wisdom that higher levels of testosterone increase the risk of prostate cancer. This belief is mostly derived from the well-documented regression of prostate cancer after surgical or pharmacological castration. However, there is an absence of scientific data supporting the concept that higher testosterone levels are associated with an increased risk of prostate cancer. Moreover, men with hypogonadism have substantial rates of prostate cancer in prostatic biopsies, suggesting that low testosterone has no protective effect against the development of prostate cancer. Moreover, prostate cancer rate is higher in elderly patients when hormonal levels are low. These results argue against an increased risk of prostate cancer with testosterone replacement therapy.",
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Castillo, OA, López-Fontana, G, Vidal-Mora, I & López Laur, JD 2015, 'Terapia de reemplazo con testosterona y cáncer de próstata: ¿la caída de un paradigma?', Medwave, vol. 15, n.º 3, pp. e6115. https://doi.org/10.5867/medwave.2015.03.6115

Terapia de reemplazo con testosterona y cáncer de próstata : ¿la caída de un paradigma? / Castillo, Octavio A.; López-Fontana, Gastón; Vidal-Mora, Ivar; López Laur, José Daniel.

En: Medwave, Vol. 15, N.º 3, 06.04.2015, p. e6115.

Resultado de la investigación: Review article

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T1 - Terapia de reemplazo con testosterona y cáncer de próstata

T2 - ¿la caída de un paradigma?

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AU - López-Fontana, Gastón

AU - Vidal-Mora, Ivar

AU - López Laur, José Daniel

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N2 - For six decades, it has been a part of the conventional medical wisdom that higher levels of testosterone increase the risk of prostate cancer. This belief is mostly derived from the well-documented regression of prostate cancer after surgical or pharmacological castration. However, there is an absence of scientific data supporting the concept that higher testosterone levels are associated with an increased risk of prostate cancer. Moreover, men with hypogonadism have substantial rates of prostate cancer in prostatic biopsies, suggesting that low testosterone has no protective effect against the development of prostate cancer. Moreover, prostate cancer rate is higher in elderly patients when hormonal levels are low. These results argue against an increased risk of prostate cancer with testosterone replacement therapy.

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