Temporal clusters of bovine Salmonella cases at a veterinary medical teaching hospital, 1996-2007

Kevin J. Cummings, Thomas J. Divers, Patrick L. McDonough, Andrea Moreno Switt, Martin Wiedmann, Lorin D. Warnick

Resultado de la investigación: Article

8 Citas (Scopus)

Resumen

The objectives of this study were to identify and characterize temporal clusters of bovine Salmonella cases at a veterinary medical teaching hospital and to determine which clusters were likely to have involved nosocomial transmission. Data on fecal Salmonella shedding status, serotype, and antimicrobial resistance were collected retrospectively for all cattle admitted to the Cornell University Equine and Farm Animal Hospital between January 1, 1996, and June 1, 2007. Pulsed-field gel electrophoresis (PFGE) was performed on all available isolates. Cluster analysis was used to identify temporal clusters of cases. A total of 5398 cattle were admitted during the study period; the prevalence of fecal Salmonella shedding among clinical suspects was 6.5%, whereas that among nonsuspects tested through routine surveillance was 2.5%. Eight temporal clusters (including 57 cattle) were investigated as possible outbreaks involving nosocomial transmission, ranging in size from 4 to 10 cases. All but one cluster were centered over the month of August or September. A total of 15 Salmonella serotypes were represented, with the most common being Typhimurium (33%), Newport (23%), and Agona (12%). Among the isolates available for PFGE analysis, there were 19 PFGE types represented. The majority of temporal clusters during the study period were not nosocomial in origin. However, two of the clusters were outbreaks directly resulting from nosocomial Salmonella transmission, based on case histories, serotype data, antimicrobial resistance patterns, and PFGE analysis. The clear seasonal pattern exhibited by these clusters underscores the need for heightened Salmonella vigilance during the late summer and early fall. The combination of statistical methods, routine bacteriologic data, and PFGE analysis is an effective means of conducting surveillance and outbreak investigations in a hospital setting.

Idioma originalEnglish
Páginas (desde-hasta)471-479
Número de páginas9
PublicaciónVector-Borne and Zoonotic Diseases
Volumen10
N.º5
DOI
EstadoPublished - 1 jun 2010

Huella dactilar

Teaching Hospitals
Salmonella
Pulsed Field Gel Electrophoresis
Disease Outbreaks
Animal Hospitals
Domestic Animals
Horses
Cluster Analysis
Serogroup

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases
  • Virology

Citar esto

Cummings, Kevin J. ; Divers, Thomas J. ; McDonough, Patrick L. ; Switt, Andrea Moreno ; Wiedmann, Martin ; Warnick, Lorin D. / Temporal clusters of bovine Salmonella cases at a veterinary medical teaching hospital, 1996-2007. En: Vector-Borne and Zoonotic Diseases. 2010 ; Vol. 10, N.º 5. pp. 471-479.
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abstract = "The objectives of this study were to identify and characterize temporal clusters of bovine Salmonella cases at a veterinary medical teaching hospital and to determine which clusters were likely to have involved nosocomial transmission. Data on fecal Salmonella shedding status, serotype, and antimicrobial resistance were collected retrospectively for all cattle admitted to the Cornell University Equine and Farm Animal Hospital between January 1, 1996, and June 1, 2007. Pulsed-field gel electrophoresis (PFGE) was performed on all available isolates. Cluster analysis was used to identify temporal clusters of cases. A total of 5398 cattle were admitted during the study period; the prevalence of fecal Salmonella shedding among clinical suspects was 6.5{\%}, whereas that among nonsuspects tested through routine surveillance was 2.5{\%}. Eight temporal clusters (including 57 cattle) were investigated as possible outbreaks involving nosocomial transmission, ranging in size from 4 to 10 cases. All but one cluster were centered over the month of August or September. A total of 15 Salmonella serotypes were represented, with the most common being Typhimurium (33{\%}), Newport (23{\%}), and Agona (12{\%}). Among the isolates available for PFGE analysis, there were 19 PFGE types represented. The majority of temporal clusters during the study period were not nosocomial in origin. However, two of the clusters were outbreaks directly resulting from nosocomial Salmonella transmission, based on case histories, serotype data, antimicrobial resistance patterns, and PFGE analysis. The clear seasonal pattern exhibited by these clusters underscores the need for heightened Salmonella vigilance during the late summer and early fall. The combination of statistical methods, routine bacteriologic data, and PFGE analysis is an effective means of conducting surveillance and outbreak investigations in a hospital setting.",
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Temporal clusters of bovine Salmonella cases at a veterinary medical teaching hospital, 1996-2007. / Cummings, Kevin J.; Divers, Thomas J.; McDonough, Patrick L.; Switt, Andrea Moreno; Wiedmann, Martin; Warnick, Lorin D.

En: Vector-Borne and Zoonotic Diseases, Vol. 10, N.º 5, 01.06.2010, p. 471-479.

Resultado de la investigación: Article

TY - JOUR

T1 - Temporal clusters of bovine Salmonella cases at a veterinary medical teaching hospital, 1996-2007

AU - Cummings, Kevin J.

AU - Divers, Thomas J.

AU - McDonough, Patrick L.

AU - Switt, Andrea Moreno

AU - Wiedmann, Martin

AU - Warnick, Lorin D.

PY - 2010/6/1

Y1 - 2010/6/1

N2 - The objectives of this study were to identify and characterize temporal clusters of bovine Salmonella cases at a veterinary medical teaching hospital and to determine which clusters were likely to have involved nosocomial transmission. Data on fecal Salmonella shedding status, serotype, and antimicrobial resistance were collected retrospectively for all cattle admitted to the Cornell University Equine and Farm Animal Hospital between January 1, 1996, and June 1, 2007. Pulsed-field gel electrophoresis (PFGE) was performed on all available isolates. Cluster analysis was used to identify temporal clusters of cases. A total of 5398 cattle were admitted during the study period; the prevalence of fecal Salmonella shedding among clinical suspects was 6.5%, whereas that among nonsuspects tested through routine surveillance was 2.5%. Eight temporal clusters (including 57 cattle) were investigated as possible outbreaks involving nosocomial transmission, ranging in size from 4 to 10 cases. All but one cluster were centered over the month of August or September. A total of 15 Salmonella serotypes were represented, with the most common being Typhimurium (33%), Newport (23%), and Agona (12%). Among the isolates available for PFGE analysis, there were 19 PFGE types represented. The majority of temporal clusters during the study period were not nosocomial in origin. However, two of the clusters were outbreaks directly resulting from nosocomial Salmonella transmission, based on case histories, serotype data, antimicrobial resistance patterns, and PFGE analysis. The clear seasonal pattern exhibited by these clusters underscores the need for heightened Salmonella vigilance during the late summer and early fall. The combination of statistical methods, routine bacteriologic data, and PFGE analysis is an effective means of conducting surveillance and outbreak investigations in a hospital setting.

AB - The objectives of this study were to identify and characterize temporal clusters of bovine Salmonella cases at a veterinary medical teaching hospital and to determine which clusters were likely to have involved nosocomial transmission. Data on fecal Salmonella shedding status, serotype, and antimicrobial resistance were collected retrospectively for all cattle admitted to the Cornell University Equine and Farm Animal Hospital between January 1, 1996, and June 1, 2007. Pulsed-field gel electrophoresis (PFGE) was performed on all available isolates. Cluster analysis was used to identify temporal clusters of cases. A total of 5398 cattle were admitted during the study period; the prevalence of fecal Salmonella shedding among clinical suspects was 6.5%, whereas that among nonsuspects tested through routine surveillance was 2.5%. Eight temporal clusters (including 57 cattle) were investigated as possible outbreaks involving nosocomial transmission, ranging in size from 4 to 10 cases. All but one cluster were centered over the month of August or September. A total of 15 Salmonella serotypes were represented, with the most common being Typhimurium (33%), Newport (23%), and Agona (12%). Among the isolates available for PFGE analysis, there were 19 PFGE types represented. The majority of temporal clusters during the study period were not nosocomial in origin. However, two of the clusters were outbreaks directly resulting from nosocomial Salmonella transmission, based on case histories, serotype data, antimicrobial resistance patterns, and PFGE analysis. The clear seasonal pattern exhibited by these clusters underscores the need for heightened Salmonella vigilance during the late summer and early fall. The combination of statistical methods, routine bacteriologic data, and PFGE analysis is an effective means of conducting surveillance and outbreak investigations in a hospital setting.

KW - Bovine

KW - Epidemiology

KW - Nosocomial

KW - Salmonella

KW - Veterinary Hospital

KW - Zoonotic

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U2 - 10.1089/vbz.2009.0068

DO - 10.1089/vbz.2009.0068

M3 - Article

C2 - 19877812

AN - SCOPUS:77951691577

VL - 10

SP - 471

EP - 479

JO - Vector-Borne and Zoonotic Diseases

JF - Vector-Borne and Zoonotic Diseases

SN - 1530-3667

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