Temporal and spatial regulation of cAMP signaling in disease: Role of cyclic nucleotide phosphodiesterases

Carolina Otero, Juan P. Peñaloza, Paula I. Rodas, Ricardo Fernández-Ramires, Luis Velasquez, Juan E. Jung

Resultado de la investigación: Article

15 Citas (Scopus)

Resumen

Since its discovery, cAMP has been proposed as one of the most versatile second messengers. The remarkable feature of cAMP to tightly control highly diverse physiological processes, including metabolism, homeostasis, secretion, muscle contraction, cell proliferation and migration, immune response, and gene transcription, is reflected by millions of different articles worldwide. Compartmentalization of cAMP in space and time, maintained by mainly phosphodiesterases, contributes to the maintenance of equilibrium inside the cell where one signal can trigger many different events. Novel cAMP sensors seem to carry out certain unexpected signaling properties of cAMP and thereby to permit delicate adaptations of biologic responses. Measuring space and time events with biosensors will increase our current knowledge on the pathophysiology of diseases, such as chronic obstructive pulmonary disease, asthma, cognitive impairment, cancer, and renal and heart failure. Further insights into the cAMP dynamics will help to optimize the pharmacological treatment for these diseases.

Idioma originalEnglish
Páginas (desde-hasta)593-607
Número de páginas15
PublicaciónFundamental and Clinical Pharmacology
Volumen28
N.º6
DOI
EstadoPublished - 1 dic 2014

Huella dactilar

Cyclic Nucleotides
Phosphoric Diester Hydrolases
Biological Adaptation
Physiological Phenomena
Biosensing Techniques
Second Messenger Systems
Muscle Contraction
Muscle Cells
Chronic Obstructive Pulmonary Disease
Cell Movement
Renal Insufficiency
Homeostasis
Asthma
Heart Failure
Maintenance
Cell Proliferation
Pharmacology
Genes
Neoplasms
Cognitive Dysfunction

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Citar esto

Otero, Carolina ; Peñaloza, Juan P. ; Rodas, Paula I. ; Fernández-Ramires, Ricardo ; Velasquez, Luis ; Jung, Juan E. / Temporal and spatial regulation of cAMP signaling in disease : Role of cyclic nucleotide phosphodiesterases. En: Fundamental and Clinical Pharmacology. 2014 ; Vol. 28, N.º 6. pp. 593-607.
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Temporal and spatial regulation of cAMP signaling in disease : Role of cyclic nucleotide phosphodiesterases. / Otero, Carolina; Peñaloza, Juan P.; Rodas, Paula I.; Fernández-Ramires, Ricardo; Velasquez, Luis; Jung, Juan E.

En: Fundamental and Clinical Pharmacology, Vol. 28, N.º 6, 01.12.2014, p. 593-607.

Resultado de la investigación: Article

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AU - Velasquez, Luis

AU - Jung, Juan E.

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