TY - JOUR
T1 - Techniques of structural characterization of dendrimers
AU - Lizama, Oscar Valdés
AU - Vilos, Cristián
AU - Duran-Lara, Estebán
N1 - Publisher Copyright:
© 2016 Bentham Science Publishers.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Currently, dendrimers are molecules widely investigated due to their strong potential for biomedical (including diagnostic, drug discovery, and drug delivery platforms) and others applications. The requirements demanded by Food and Drug Administration (FDA) of a new drug application involve several analytical techniques for characterization, which allow understanding the properties of the novel platforms, and to predict their interactions with the biological environment. This work proposes a full description to perform the analytical characterization of dendrimers, including techniques for evaluating the morphology, shape, molecular weight, polydispersity, and purity; as well as methods for the synthesize and conjugation with molecules for targeting.
AB - Currently, dendrimers are molecules widely investigated due to their strong potential for biomedical (including diagnostic, drug discovery, and drug delivery platforms) and others applications. The requirements demanded by Food and Drug Administration (FDA) of a new drug application involve several analytical techniques for characterization, which allow understanding the properties of the novel platforms, and to predict their interactions with the biological environment. This work proposes a full description to perform the analytical characterization of dendrimers, including techniques for evaluating the morphology, shape, molecular weight, polydispersity, and purity; as well as methods for the synthesize and conjugation with molecules for targeting.
KW - Dendrimers
KW - Differential scanning
KW - Mass spectrometry
KW - Microscopy
KW - NMR
KW - Rheology
KW - Scattering techniques
KW - Spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=84989225426&partnerID=8YFLogxK
U2 - 10.2174/1385272820666160608095009
DO - 10.2174/1385272820666160608095009
M3 - Review article
AN - SCOPUS:84989225426
SN - 1385-2728
VL - 20
SP - 2591
EP - 2605
JO - Current Organic Chemistry
JF - Current Organic Chemistry
IS - 24
ER -