Targeted nanoparticles for colorectal cancer

Bruno A. Cisterna, Nazila Kamaly, Won Il Choi, Ali Tavakkoli, Omid C. Farokhzad, Cristian Vilos

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

52 Citas (Scopus)

Resumen

Colorectal cancer (CRC) is highly prevalent worldwide, and despite notable progress in treatment still leads to significant morbidity and mortality. The use of nanoparticles as a drug delivery system has become one of the most promising strategies for cancer therapy. Targeted nanoparticles could take advantage of differentially expressed molecules on the surface of tumor cells, providing effective release of cytotoxic drugs. Several efforts have recently reported the use of diverse molecules as ligands on the surface of nanoparticles to interact with the tumor cells, enabling the effective delivery of antitumor agents. Here, we present recent advances in targeted nanoparticles against CRC and discuss the promising use of ligands and cellular targets in potential strategies for the treatment of CRCs.

Idioma originalInglés
Páginas (desde-hasta)2443-2456
Número de páginas14
PublicaciónNanomedicine
Volumen11
N.º18
DOI
EstadoPublicada - sep 2016

Áreas temáticas de ASJC Scopus

  • Bioingeniería
  • Medicina (miscelánea)
  • Ingeniería biomédica
  • Ciencia de los materiales (todo)

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