Targeted brain delivery nanoparticles for malignant gliomas

Mauricio P. Pinto, Maximiliano Arce, Basit Yameen, Cristian Vilos

Resultado de la investigación: Review article

18 Citas (Scopus)

Resumen

Brain tumors display the highest mortality rates of all childhood cancers, and over the last decade its prevalence has steadily increased in elderly. To date, effective treatments for brain tumors and particularly for malignant gliomas remain a challenge mainly due to the low permeability and high selectivity of the blood-brain barrier (BBB) to conventional anticancer drugs. In recent years, the elucidation of the cellular mechanisms involved in the transport of substances into the brain has boosted the development of therapeutic-targeted nanoparticles (NPs) with the ability to cross the BBB. Here, we present a comprehensive overview of the available therapeutic strategies developed against malignant gliomas based on 'actively targeted' NPs, the challenges of crossing the BBB and blood-brain tumor barrier as well as its mechanisms and a critical assessment of clinical studies that have used targeted NPs for the treatment of malignant gliomas. Finally, we discuss the potential of actively targeted NP-based strategies in clinical settings, its possible side effects and future directions for therapeutic applications. First draft submitted: 4 October 2016; Accepted for publication: 14 October 2016; Published online: 23 November 201.

Idioma originalEnglish
Páginas (desde-hasta)59-72
Número de páginas14
PublicaciónNanomedicine
Volumen12
N.º1
DOI
EstadoPublished - 1 ene 2017

Huella dactilar

Glioma
Nanoparticles
Brain
Blood-Brain Barrier
Tumors
Brain Neoplasms
Therapeutics
Blood
Publications
Permeability
Pharmaceutical Preparations
Mortality
Neoplasms

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

Citar esto

Pinto, M. P., Arce, M., Yameen, B., & Vilos, C. (2017). Targeted brain delivery nanoparticles for malignant gliomas. Nanomedicine, 12(1), 59-72. https://doi.org/10.2217/nnm-2016-0307
Pinto, Mauricio P. ; Arce, Maximiliano ; Yameen, Basit ; Vilos, Cristian. / Targeted brain delivery nanoparticles for malignant gliomas. En: Nanomedicine. 2017 ; Vol. 12, N.º 1. pp. 59-72.
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Pinto, MP, Arce, M, Yameen, B & Vilos, C 2017, 'Targeted brain delivery nanoparticles for malignant gliomas', Nanomedicine, vol. 12, n.º 1, pp. 59-72. https://doi.org/10.2217/nnm-2016-0307

Targeted brain delivery nanoparticles for malignant gliomas. / Pinto, Mauricio P.; Arce, Maximiliano; Yameen, Basit; Vilos, Cristian.

En: Nanomedicine, Vol. 12, N.º 1, 01.01.2017, p. 59-72.

Resultado de la investigación: Review article

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AU - Vilos, Cristian

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N2 - Brain tumors display the highest mortality rates of all childhood cancers, and over the last decade its prevalence has steadily increased in elderly. To date, effective treatments for brain tumors and particularly for malignant gliomas remain a challenge mainly due to the low permeability and high selectivity of the blood-brain barrier (BBB) to conventional anticancer drugs. In recent years, the elucidation of the cellular mechanisms involved in the transport of substances into the brain has boosted the development of therapeutic-targeted nanoparticles (NPs) with the ability to cross the BBB. Here, we present a comprehensive overview of the available therapeutic strategies developed against malignant gliomas based on 'actively targeted' NPs, the challenges of crossing the BBB and blood-brain tumor barrier as well as its mechanisms and a critical assessment of clinical studies that have used targeted NPs for the treatment of malignant gliomas. Finally, we discuss the potential of actively targeted NP-based strategies in clinical settings, its possible side effects and future directions for therapeutic applications. First draft submitted: 4 October 2016; Accepted for publication: 14 October 2016; Published online: 23 November 201.

AB - Brain tumors display the highest mortality rates of all childhood cancers, and over the last decade its prevalence has steadily increased in elderly. To date, effective treatments for brain tumors and particularly for malignant gliomas remain a challenge mainly due to the low permeability and high selectivity of the blood-brain barrier (BBB) to conventional anticancer drugs. In recent years, the elucidation of the cellular mechanisms involved in the transport of substances into the brain has boosted the development of therapeutic-targeted nanoparticles (NPs) with the ability to cross the BBB. Here, we present a comprehensive overview of the available therapeutic strategies developed against malignant gliomas based on 'actively targeted' NPs, the challenges of crossing the BBB and blood-brain tumor barrier as well as its mechanisms and a critical assessment of clinical studies that have used targeted NPs for the treatment of malignant gliomas. Finally, we discuss the potential of actively targeted NP-based strategies in clinical settings, its possible side effects and future directions for therapeutic applications. First draft submitted: 4 October 2016; Accepted for publication: 14 October 2016; Published online: 23 November 201.

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