T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour

Sarah Nuñez, Juan Jose Saez, Dominique Fernandez, Felipe Flores-Santibañez, Karla Alvarez, Gabriela Tejon, Paulina Ruiz, Paula Maldonado, Yessia Hidalgo, Valeria Manriquez, Maria Rosa Bono, Mario Rosemblatt, Daniela Sauma

Resultado de la investigación: Article

15 Citas (Scopus)

Resumen

T helper type 17 (Th17) lymphocytes are found in high frequency in tumour-burdened animals and cancer patients. These lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, have a well-defined role in the development of inflammatory and autoimmune pathologies; however, their function in tumour immunity is less clear. We explored possible opposing anti-tumour and tumour-promoting functions of Th17 cells by evaluating tumour growth and the ability to promote tumour infiltration of myeloid-derived suppressor cells (MDSC), regulatory T cells and CD4+ interferon-γ+ cells in a retinoic acid-like orphan receptor γt (RORγt) -deficient mouse model. A reduced percentage of Th17 cells in the tumour microenvironment in RORγt-deficient mice led to enhanced tumour growth, that could be reverted by adoptive transfer of Th17 cells. Differences in tumour growth were not associated with changes in the accumulation or suppressive function of MDSC and regulatory T cells but were related to a decrease in the proportion of CD4+ T cells in the tumour. Our results suggest that Th17 cells do not affect the recruitment of immunosuppressive populations but favour the recruitment of effector Th1 cells to the tumour, thereby promoting anti-tumour responses.

Idioma originalEnglish
Páginas (desde-hasta)61-71
Número de páginas11
PublicaciónImmunology
Volumen139
N.º1
DOI
EstadoPublished - may 2013

Huella dactilar

Th17 Cells
Th1 Cells
Immunity
Neoplasms
Regulatory T-Lymphocytes
Growth
Tumor Microenvironment
Interleukin-17
Adoptive Transfer
Immunosuppressive Agents
Helper-Inducer T-Lymphocytes
Tretinoin
Interferons

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Citar esto

Nuñez, S., Saez, J. J., Fernandez, D., Flores-Santibañez, F., Alvarez, K., Tejon, G., ... Sauma, D. (2013). T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour. Immunology, 139(1), 61-71. https://doi.org/10.1111/imm.12055
Nuñez, Sarah ; Saez, Juan Jose ; Fernandez, Dominique ; Flores-Santibañez, Felipe ; Alvarez, Karla ; Tejon, Gabriela ; Ruiz, Paulina ; Maldonado, Paula ; Hidalgo, Yessia ; Manriquez, Valeria ; Bono, Maria Rosa ; Rosemblatt, Mario ; Sauma, Daniela. / T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour. En: Immunology. 2013 ; Vol. 139, N.º 1. pp. 61-71.
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abstract = "T helper type 17 (Th17) lymphocytes are found in high frequency in tumour-burdened animals and cancer patients. These lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, have a well-defined role in the development of inflammatory and autoimmune pathologies; however, their function in tumour immunity is less clear. We explored possible opposing anti-tumour and tumour-promoting functions of Th17 cells by evaluating tumour growth and the ability to promote tumour infiltration of myeloid-derived suppressor cells (MDSC), regulatory T cells and CD4+ interferon-γ+ cells in a retinoic acid-like orphan receptor γt (RORγt) -deficient mouse model. A reduced percentage of Th17 cells in the tumour microenvironment in RORγt-deficient mice led to enhanced tumour growth, that could be reverted by adoptive transfer of Th17 cells. Differences in tumour growth were not associated with changes in the accumulation or suppressive function of MDSC and regulatory T cells but were related to a decrease in the proportion of CD4+ T cells in the tumour. Our results suggest that Th17 cells do not affect the recruitment of immunosuppressive populations but favour the recruitment of effector Th1 cells to the tumour, thereby promoting anti-tumour responses.",
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Nuñez, S, Saez, JJ, Fernandez, D, Flores-Santibañez, F, Alvarez, K, Tejon, G, Ruiz, P, Maldonado, P, Hidalgo, Y, Manriquez, V, Bono, MR, Rosemblatt, M & Sauma, D 2013, 'T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour', Immunology, vol. 139, n.º 1, pp. 61-71. https://doi.org/10.1111/imm.12055

T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour. / Nuñez, Sarah; Saez, Juan Jose; Fernandez, Dominique; Flores-Santibañez, Felipe; Alvarez, Karla; Tejon, Gabriela; Ruiz, Paulina; Maldonado, Paula; Hidalgo, Yessia; Manriquez, Valeria; Bono, Maria Rosa; Rosemblatt, Mario; Sauma, Daniela.

En: Immunology, Vol. 139, N.º 1, 05.2013, p. 61-71.

Resultado de la investigación: Article

TY - JOUR

T1 - T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour

AU - Nuñez, Sarah

AU - Saez, Juan Jose

AU - Fernandez, Dominique

AU - Flores-Santibañez, Felipe

AU - Alvarez, Karla

AU - Tejon, Gabriela

AU - Ruiz, Paulina

AU - Maldonado, Paula

AU - Hidalgo, Yessia

AU - Manriquez, Valeria

AU - Bono, Maria Rosa

AU - Rosemblatt, Mario

AU - Sauma, Daniela

PY - 2013/5

Y1 - 2013/5

N2 - T helper type 17 (Th17) lymphocytes are found in high frequency in tumour-burdened animals and cancer patients. These lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, have a well-defined role in the development of inflammatory and autoimmune pathologies; however, their function in tumour immunity is less clear. We explored possible opposing anti-tumour and tumour-promoting functions of Th17 cells by evaluating tumour growth and the ability to promote tumour infiltration of myeloid-derived suppressor cells (MDSC), regulatory T cells and CD4+ interferon-γ+ cells in a retinoic acid-like orphan receptor γt (RORγt) -deficient mouse model. A reduced percentage of Th17 cells in the tumour microenvironment in RORγt-deficient mice led to enhanced tumour growth, that could be reverted by adoptive transfer of Th17 cells. Differences in tumour growth were not associated with changes in the accumulation or suppressive function of MDSC and regulatory T cells but were related to a decrease in the proportion of CD4+ T cells in the tumour. Our results suggest that Th17 cells do not affect the recruitment of immunosuppressive populations but favour the recruitment of effector Th1 cells to the tumour, thereby promoting anti-tumour responses.

AB - T helper type 17 (Th17) lymphocytes are found in high frequency in tumour-burdened animals and cancer patients. These lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, have a well-defined role in the development of inflammatory and autoimmune pathologies; however, their function in tumour immunity is less clear. We explored possible opposing anti-tumour and tumour-promoting functions of Th17 cells by evaluating tumour growth and the ability to promote tumour infiltration of myeloid-derived suppressor cells (MDSC), regulatory T cells and CD4+ interferon-γ+ cells in a retinoic acid-like orphan receptor γt (RORγt) -deficient mouse model. A reduced percentage of Th17 cells in the tumour microenvironment in RORγt-deficient mice led to enhanced tumour growth, that could be reverted by adoptive transfer of Th17 cells. Differences in tumour growth were not associated with changes in the accumulation or suppressive function of MDSC and regulatory T cells but were related to a decrease in the proportion of CD4+ T cells in the tumour. Our results suggest that Th17 cells do not affect the recruitment of immunosuppressive populations but favour the recruitment of effector Th1 cells to the tumour, thereby promoting anti-tumour responses.

KW - Anti-tumour immunity

KW - Rorγt

KW - T helper type 1 cells

KW - T helper type 17 cells

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U2 - 10.1111/imm.12055

DO - 10.1111/imm.12055

M3 - Article

C2 - 23278668

AN - SCOPUS:84876070070

VL - 139

SP - 61

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JO - Immunology

JF - Immunology

SN - 0019-2805

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