T-cell homing to the gut mucosa: General concepts and methodological considerations

Jaime De Calisto, Eduardo J. Villablanca, Sen Wang, Maria R. Bono, Mario Rosemblatt, J. Rodrigo Mora

Resultado de la investigación: Contribución a los tipos de informe/libroCapítulorevisión exhaustiva

14 Citas (Scopus)

Resumen

Effector/memory T cells can migrate to most extra-lymphoid tissues in the body. However, migration to the intestinal mucosa requires the expression of very specific homing receptors on T cells, integrin α4β7 and chemokine receptor CCR9. These receptors are induced by all-trans retinoic acid (RA), a vitamin A metabolite that is specifically synthesized by gut-associated dendritic cells (DC), but not by extra-intestinal DC. Here we summarize some general concepts on T cell homing with an emphasis on the gut mucosa. We also discuss experimental strategies to generate gut-homing T cells in vivo and in vitro and the techniques to track gut-homing T cells.

Idioma originalInglés
Título de la publicación alojadaIntegrin and Cell Adhesion Molecules
Páginas411-434
Número de páginas24
Volumen757
DOI
EstadoPublicada - 2011

Serie de la publicación

NombreMethods in Molecular Biology
Volumen757
ISSN (versión impresa)10643745

Áreas temáticas de ASJC Scopus

  • Biología molecular
  • Genética

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