Systemic synergism between codeine and morphine in three pain models in mice

Hugo F. Miranda, Viviana Noriega, Ramiro J. Zepeda, Fernando Sierralta, Juan C. Prieto

Resultado de la investigación: Article

12 Citas (Scopus)

Resumen

Background: The combination of two analgesic agents offers advantages in pain treatment. Codeine and morphine analgesia is due to activation of opioid receptor subtypes. Methods: This study, performed in mice using isobolographic analysis, evaluated the type of interaction in intraperitoneal (ip) or intrathecal (it) coadministration of codeine and morphine, in three nociceptive behavioral models. Results: Intrathecal morphine resulted to be 7.5 times more potent than ip morphine in the writhing test, 55.6 times in the tail flick test and 1.7 times in phase II of the orofacial formalin test; however, in phase I of the same test ip was 1.2 times more potent than it morphine. Intrathecal codeine resulted being 3.4 times more potent than ip codeine in the writhing test, 1.6 times in the tail flick test, 2.5 times in phase I and 6.7 times in phase II of the orofacial formalin test. Opioid coadministration had a synergistic effect in the acute tonic pain (acetic acid writhing test), acute phasic pain (tail flick test) and inflammatory pain (orofacial formalin test). The interaction index ranged between 0.284 (writhing ip) and 0.440 (orofacial formalin phase II ip). Conclusion: This synergy may relate to the different pathways of pain transmission and to the different intracellular signal transduction. The present findings also raise the possibility of potential clinical advantages in combining opioids in pain management.

Idioma originalEnglish
Páginas (desde-hasta)80-88
Número de páginas9
PublicaciónPharmacological Reports
Volumen65
N.º1
DOI
EstadoPublished - 1 ene 2013

Huella dactilar

Codeine
Morphine
Pain
Pain Measurement
Tail
Acute Pain
Opioid Analgesics
Facial Pain
Opioid Receptors
Pain Management
Acetic Acid
Analgesia
Formaldehyde
Analgesics
Signal Transduction

ASJC Scopus subject areas

  • Pharmacology

Citar esto

Miranda, H. F., Noriega, V., Zepeda, R. J., Sierralta, F., & Prieto, J. C. (2013). Systemic synergism between codeine and morphine in three pain models in mice. Pharmacological Reports, 65(1), 80-88. https://doi.org/10.1016/S1734-1140(13)70966-6
Miranda, Hugo F. ; Noriega, Viviana ; Zepeda, Ramiro J. ; Sierralta, Fernando ; Prieto, Juan C. / Systemic synergism between codeine and morphine in three pain models in mice. En: Pharmacological Reports. 2013 ; Vol. 65, N.º 1. pp. 80-88.
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Miranda, HF, Noriega, V, Zepeda, RJ, Sierralta, F & Prieto, JC 2013, 'Systemic synergism between codeine and morphine in three pain models in mice', Pharmacological Reports, vol. 65, n.º 1, pp. 80-88. https://doi.org/10.1016/S1734-1140(13)70966-6

Systemic synergism between codeine and morphine in three pain models in mice. / Miranda, Hugo F.; Noriega, Viviana; Zepeda, Ramiro J.; Sierralta, Fernando; Prieto, Juan C.

En: Pharmacological Reports, Vol. 65, N.º 1, 01.01.2013, p. 80-88.

Resultado de la investigación: Article

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T1 - Systemic synergism between codeine and morphine in three pain models in mice

AU - Miranda, Hugo F.

AU - Noriega, Viviana

AU - Zepeda, Ramiro J.

AU - Sierralta, Fernando

AU - Prieto, Juan C.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background: The combination of two analgesic agents offers advantages in pain treatment. Codeine and morphine analgesia is due to activation of opioid receptor subtypes. Methods: This study, performed in mice using isobolographic analysis, evaluated the type of interaction in intraperitoneal (ip) or intrathecal (it) coadministration of codeine and morphine, in three nociceptive behavioral models. Results: Intrathecal morphine resulted to be 7.5 times more potent than ip morphine in the writhing test, 55.6 times in the tail flick test and 1.7 times in phase II of the orofacial formalin test; however, in phase I of the same test ip was 1.2 times more potent than it morphine. Intrathecal codeine resulted being 3.4 times more potent than ip codeine in the writhing test, 1.6 times in the tail flick test, 2.5 times in phase I and 6.7 times in phase II of the orofacial formalin test. Opioid coadministration had a synergistic effect in the acute tonic pain (acetic acid writhing test), acute phasic pain (tail flick test) and inflammatory pain (orofacial formalin test). The interaction index ranged between 0.284 (writhing ip) and 0.440 (orofacial formalin phase II ip). Conclusion: This synergy may relate to the different pathways of pain transmission and to the different intracellular signal transduction. The present findings also raise the possibility of potential clinical advantages in combining opioids in pain management.

AB - Background: The combination of two analgesic agents offers advantages in pain treatment. Codeine and morphine analgesia is due to activation of opioid receptor subtypes. Methods: This study, performed in mice using isobolographic analysis, evaluated the type of interaction in intraperitoneal (ip) or intrathecal (it) coadministration of codeine and morphine, in three nociceptive behavioral models. Results: Intrathecal morphine resulted to be 7.5 times more potent than ip morphine in the writhing test, 55.6 times in the tail flick test and 1.7 times in phase II of the orofacial formalin test; however, in phase I of the same test ip was 1.2 times more potent than it morphine. Intrathecal codeine resulted being 3.4 times more potent than ip codeine in the writhing test, 1.6 times in the tail flick test, 2.5 times in phase I and 6.7 times in phase II of the orofacial formalin test. Opioid coadministration had a synergistic effect in the acute tonic pain (acetic acid writhing test), acute phasic pain (tail flick test) and inflammatory pain (orofacial formalin test). The interaction index ranged between 0.284 (writhing ip) and 0.440 (orofacial formalin phase II ip). Conclusion: This synergy may relate to the different pathways of pain transmission and to the different intracellular signal transduction. The present findings also raise the possibility of potential clinical advantages in combining opioids in pain management.

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