Systemic oxidative stress and endothelial dysfunction is associated with an attenuated acute vascular response to inhaled prostanoid in pulmonary artery hypertension patients

Luigi A. Gabrielli, Pablo F. Castro, Ivan Godoy, Rosemarie Mellado, Robert C. Bourge, Hernan Alcaino, Mario Chiong, Douglas Greig, Hugo E. Verdejo, Mario Navarro, Rafael Lopez, Barbra Toro, Clara Quiroga, Guillermo Díaz-Araya, Sergio Lavandero, Lorena Garcia

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

24 Citas (Scopus)

Resumen

Background: Systemic endothelial dysfunction and increased oxidative stress have been observed in pulmonary arterial hypertension (PAH). We evaluate whether oxidative stress and endothelial dysfunction are associated with acute pulmonary vascular bed response to an inhaled prostanoid in PAH patients. Methods: Fourteen idiopathic PAH patients and 14 controls were included. Oxidative stress was assessed through plasma malondialdehyde (MDA) levels and xanthine oxidase (XO) and endothelial-bound superoxide dismutase (eSOD) activity. Brachial artery endothelial-dependent flow-mediated vasodilation (FMD) was used to evaluate endothelial function. Hemodynamic response to inhaled iloprost was assessed with transthoracic echocardiography. Results: PAH patients showed impaired FMD (2.8 ± 0.6 vs. 10.7 ± 0.6%, P <.01), increased MDA levels and XO activity (0.6 ± 0.2 vs. 0.3 ± 0.2 μM, P <.01 and 0.04 ± 0.01 vs. 0.03 ± 0.01 U/mL, P =.02, respectively) and decreased eSOD activity (235 ± 23 vs. 461 ± 33 AUC, P <.01). Iloprost improved right cardiac output (3.7 ± 0.6 to 4.1 ± 1.2 L/min, P =.02) and decreased pulmonary vascular resistance (4.1 ± 1.1 to 2.9 ± 0.9 Wood U, P =.01). Changes in right cardiac output after prostanoid inhalation correlated significantly with baseline eSOD activity and FMD (Rho: 0.61, P <.01 and Rho: 0.63, P =.01, respectively). Conclusion: PAH patients show increased systemic oxidative stress and endothelial dysfunction markers. Response to inhaled prostanoid is inversely related to both parameters.

Idioma originalInglés
Páginas (desde-hasta)1012-1017
Número de páginas6
PublicaciónJournal of Cardiac Failure
Volumen17
N.º12
DOI
EstadoPublicada - 1 dic 2011

Áreas temáticas de ASJC Scopus

  • Cardiología y medicina cardiovascular

Huella

Profundice en los temas de investigación de 'Systemic oxidative stress and endothelial dysfunction is associated with an attenuated acute vascular response to inhaled prostanoid in pulmonary artery hypertension patients'. En conjunto forman una huella única.

Citar esto