Systemic Inflammation but not Oxidative Stress Is Associated with Physical Performance in Moderate Chronic Obstructive Pulmonary Disease

Luis Peñailillo, Claudia Miranda-Fuentes, Sebastián Gutiérrez, Sebastián García-Vicencio, Sebastián Jannas-Vela, Cristian Campos Acevedo, Reyna S. Peñailillo

Producción científica: Contribución a los tipos de informe/libroCapítulorevisión exhaustiva

1 Cita (Scopus)

Resumen

Chronic obstructive pulmonary disease (COPD) patients manifest muscle dysfunction and impaired muscle oxidative capacity, which result in reduced exercise capacity and poor health status. The aim of this study was to compare the physical performance, systemic inflammation, and oxidative stress of patients with moderate COPD, and to associate physical performance with inflammatory and oxidative stress plasma markers. Twenty CONTROL (n = 10) and moderate COPD (n = 10) patients participated in this study. Systematic inflammation and oxidative stress plasma markers, maximal aerobic capacity (VO2peak), and maximal isometric strength (MVIC) of the knee extensor (KE) muscles were measured. VO2peak was 31.3% greater in CONTROL compared to COPD (P = 0.006). The MVIC strength of the KE was 43.9% greater in CONTROL compared to COPD (P = 0.002). Tumor necrosis factor-alpha (TNF-α) was 79.6% greater in COPD compared to CONTROL (P < 0.001). Glutathione peroxidase activity (GPx) activity was 27.5% lesser in COPD compared to CONTROL (P = 0.05). TNF-α concentration was correlated with KE MVC strength (R = −0.48; P = 0.045) and VO2peak (R = −0.58; P = 0.01). Meanwhile, malondialdehyde (MDA) and GPx activity were not associated with KE strength or VO2peak (P = 0.74 and P = 0.14, respectively). COPD patients showed lesser muscle strength and aerobic capacity than healthy control individuals. Furthermore, patients with COPD showed greater systemic inflammation and lesser antioxidant capacity than healthy counterparts. A moderate association was evident between levels of systemic inflammation and physical performance variables.

Idioma originalInglés
Título de la publicación alojadaAdvances in Experimental Medicine and Biology
EditorialSpringer
Páginas121-130
Número de páginas10
DOI
EstadoPublicada - 2024

Serie de la publicación

NombreAdvances in Experimental Medicine and Biology
Volumen1450
ISSN (versión impresa)0065-2598
ISSN (versión digital)2214-8019

Áreas temáticas de ASJC Scopus

  • Bioquímica, Genética y Biología Molecular General

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