SYNTHESIS, CHEMICAL IDENTIFICATION, DRUG RELEASE AND DOCKING STUDIES OF THE AMLODIPINE-CHITOSAN NANOBIOPOLYMER COMPOSITE

Rodrigo Ramirez-Tagle, Guillermo Salgado-Moran, David Mendez-Luna, Jose Correa-Basurto, Lorena Gerli Candia, Wilson Cardona Villada, Luis H. Mendoza-Huizar

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

A new amlodipine-chitosan nanocomposite was built using amlodipine nanoparticles as primary scaffolds by spontaneous emulsification, and its complete elucidation was performed by using several spectrometric techniques. Our results indicate that the amlodipine-chitosan nanocomposite has better solubility than amlodipine at pH 7.4 with a nearly all the drug substance dissolved (97%) by the final time-point measured. The docking study support the existence of intermolecular interactions are established between amlodipine and chitosan.

Idioma originalInglés
Páginas (desde-hasta)5063-5066
Número de páginas4
PublicaciónJournal of the Chilean Chemical Society
Volumen65
N.º1
DOI
EstadoPublicada - ene 2021

Áreas temáticas de ASJC Scopus

  • Química (todo)

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