Synthesis and evaluation of diverse analogs of amygdalin as potential peptidomimetics of peptide T

Eyleen Araya, Alex Rodriguez, Jaime Rubio, Alessandro Spada, Jesus Joglar, Amadeu Llebaria, Carmen Lagunas, Andres G. Fernandez, Susanna Spisani, Juan J. Perez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

9 Citas (Scopus)

Resumen

Peptide T (ASTTTNYT) is a promising molecule to prevent the neuropsychometric symptoms of patients suffering AIDS and for the treatment of psoriasis. In order to fully prove its therapeutic benefits, efforts were put forward to design peptidomimetics of the peptide. In this direction, in a recent computational study the natural product amygdalin was identified as a prospective peptidomimetic of the peptide and later proved to exhibit a similar chemotactic profile to the peptide. However, the cyanide moiety of amygdalin provides to the molecule a toxic profile. The present study reports the synthesis of a set of amygdalin analogs lacking the cyanide group with improved chemotactic profiles.

Idioma originalInglés
Páginas (desde-hasta)1493-1496
Número de páginas4
PublicaciónBioorganic and Medicinal Chemistry Letters
Volumen15
N.º5
DOI
EstadoPublicada - 1 mar 2005

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Medicina molecular
  • Biología molecular
  • Ciencias farmacéuticas
  • Descubrimiento de medicamentos
  • Bioquímica clínica
  • Química orgánica

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