Synthesis and assembly of hepatitis B virus surface antigen particles in yeast

Pablo Valenzuela, Angelica Medina, William J. Rutter, Gustav Ammerer, Benjamin D. Hall

Resultado de la investigación: Contribución a una revistaArtículo

561 Citas (Scopus)

Resumen

The surface antigen of hepatitis B virus (HBsAg) has been synthesized in the yeast Saccharomyces cerevisiae by using an expression vector that employs the 5′-flanking region of yeast alcohol dehydrogenase I as a promoter to transcribe surface antigen coding sequences. The protein synthesized in yeast is assembled into particles having properties similar to the 22-nm particles secreted by human cells.

Idioma originalInglés
Páginas (desde-hasta)347-350
Número de páginas4
PublicaciónNature
Volumen298
N.º5872
DOI
EstadoPublicada - 1982

Áreas temáticas de ASJC Scopus

  • General

Huella Profundice en los temas de investigación de 'Synthesis and assembly of hepatitis B virus surface antigen particles in yeast'. En conjunto forman una huella única.

  • Citar esto

    Valenzuela, P., Medina, A., Rutter, W. J., Ammerer, G., & Hall, B. D. (1982). Synthesis and assembly of hepatitis B virus surface antigen particles in yeast. Nature, 298(5872), 347-350. https://doi.org/10.1038/298347a0