Synthesis and assembly of hepatitis B virus surface antigen particles in yeast

Pablo Valenzuela, Angelica Medina, William J. Rutter, Gustav Ammerer, Benjamin D. Hall

Resultado de la investigación: Article

542 Citas (Scopus)

Resumen

The surface antigen of hepatitis B virus (HBsAg) has been synthesized in the yeast Saccharomyces cerevisiae by using an expression vector that employs the 5′-flanking region of yeast alcohol dehydrogenase I as a promoter to transcribe surface antigen coding sequences. The protein synthesized in yeast is assembled into particles having properties similar to the 22-nm particles secreted by human cells.

Idioma originalEnglish
Páginas (desde-hasta)347-350
Número de páginas4
PublicaciónNature
Volumen298
N.º5872
DOI
EstadoPublished - 1982

Huella dactilar

Alcohol Dehydrogenase
Surface Antigens
Hepatitis B Surface Antigens
Hepatitis B virus
Yeasts
5' Flanking Region
Saccharomyces cerevisiae
Proteins

ASJC Scopus subject areas

  • General

Citar esto

Valenzuela, P., Medina, A., Rutter, W. J., Ammerer, G., & Hall, B. D. (1982). Synthesis and assembly of hepatitis B virus surface antigen particles in yeast. Nature, 298(5872), 347-350. https://doi.org/10.1038/298347a0
Valenzuela, Pablo ; Medina, Angelica ; Rutter, William J. ; Ammerer, Gustav ; Hall, Benjamin D. / Synthesis and assembly of hepatitis B virus surface antigen particles in yeast. En: Nature. 1982 ; Vol. 298, N.º 5872. pp. 347-350.
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Valenzuela, P, Medina, A, Rutter, WJ, Ammerer, G & Hall, BD 1982, 'Synthesis and assembly of hepatitis B virus surface antigen particles in yeast', Nature, vol. 298, n.º 5872, pp. 347-350. https://doi.org/10.1038/298347a0

Synthesis and assembly of hepatitis B virus surface antigen particles in yeast. / Valenzuela, Pablo; Medina, Angelica; Rutter, William J.; Ammerer, Gustav; Hall, Benjamin D.

En: Nature, Vol. 298, N.º 5872, 1982, p. 347-350.

Resultado de la investigación: Article

TY - JOUR

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AU - Medina, Angelica

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AU - Ammerer, Gustav

AU - Hall, Benjamin D.

PY - 1982

Y1 - 1982

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Valenzuela P, Medina A, Rutter WJ, Ammerer G, Hall BD. Synthesis and assembly of hepatitis B virus surface antigen particles in yeast. Nature. 1982;298(5872):347-350. https://doi.org/10.1038/298347a0