Synthesis and assembly of hepatitis B virus surface antigen particles in yeast

Pablo Valenzuela; Angelica Medina; William J. Rutter; Gustav Ammerer; Benjamin D. Hall

doi:10.1038/298347a0

Synthesis and assembly of hepatitis B virus surface antigen particles in yeast

Pablo Valenzuela, Angelica Medina, William J. Rutter, Gustav Ammerer, Benjamin D. Hall

Facultad de Ciencias de la Vida

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

630 Citas (Scopus)

Resumen

The surface antigen of hepatitis B virus (HBsAg) has been synthesized in the yeast Saccharomyces cerevisiae by using an expression vector that employs the 5′-flanking region of yeast alcohol dehydrogenase I as a promoter to transcribe surface antigen coding sequences. The protein synthesized in yeast is assembled into particles having properties similar to the 22-nm particles secreted by human cells.

Idioma original	Inglés
Páginas (desde-hasta)	347-350
Número de páginas	4
Publicación	Nature
Volumen	298
N.º	5872
DOI	https://doi.org/10.1038/298347a0
Estado	Publicada - 1982

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title = "Synthesis and assembly of hepatitis B virus surface antigen particles in yeast",

abstract = "The surface antigen of hepatitis B virus (HBsAg) has been synthesized in the yeast Saccharomyces cerevisiae by using an expression vector that employs the 5′-flanking region of yeast alcohol dehydrogenase I as a promoter to transcribe surface antigen coding sequences. The protein synthesized in yeast is assembled into particles having properties similar to the 22-nm particles secreted by human cells.",

author = "Pablo Valenzuela and Angelica Medina and Rutter, {William J.} and Gustav Ammerer and Hall, {Benjamin D.}",

year = "1982",

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T1 - Synthesis and assembly of hepatitis B virus surface antigen particles in yeast

AU - Valenzuela, Pablo

AU - Medina, Angelica

AU - Rutter, William J.

AU - Ammerer, Gustav

AU - Hall, Benjamin D.

PY - 1982

Y1 - 1982

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AB - The surface antigen of hepatitis B virus (HBsAg) has been synthesized in the yeast Saccharomyces cerevisiae by using an expression vector that employs the 5′-flanking region of yeast alcohol dehydrogenase I as a promoter to transcribe surface antigen coding sequences. The protein synthesized in yeast is assembled into particles having properties similar to the 22-nm particles secreted by human cells.

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U2 - 10.1038/298347a0

DO - 10.1038/298347a0

M3 - Article

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AN - SCOPUS:0019985965

SN - 0028-0836

VL - 298

SP - 347

EP - 350

JO - Nature

JF - Nature

IS - 5872

ER -

Synthesis and assembly of hepatitis B virus surface antigen particles in yeast

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