Synthesis and assembly in yeast of hepatitis b surface antigen particles containing the polyalbumin receptor

Pablo Valenzuela; Doris Coit; Ching H. Kuo

doi:10.1038/nbt0485-317

Synthesis and assembly in yeast of hepatitis b surface antigen particles containing the polyalbumin receptor

Pablo Valenzuela
, Doris Coit
, Ching H. Kuo

Facultad de Ciencias de la Vida

Producción científica: Contribución a una revista › Carta › revisión exhaustiva

40 Citas (Scopus)

Resumen

Yeast cells are genetically engineered to synthesize and assemble hepatitis B surface antigen particles containing 55 additional amino acids encoded by the hepatitis B virus preS gene. These particles are composed of a 28,000 dalton protein and efficiently bind polymerized human albumin. Antibodies to the polyalbumin receptor epitope of this particle may interfere with the postulated polyalbumin-mediated binding of HBV to hepatocytes and may therefore be particularly efficient in preventing the disease.

Idioma original	Inglés
Páginas (desde-hasta)	317-320
Número de páginas	4
Publicación	Bio/Technology
Volumen	3
N.º	4
DOI	https://doi.org/10.1038/nbt0485-317
Estado	Publicada - 1 ene. 1985

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Áreas temáticas de ASJC Scopus

Biotecnología

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10.1038/nbt0485-317

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title = "Synthesis and assembly in yeast of hepatitis b surface antigen particles containing the polyalbumin receptor",

abstract = "Yeast cells are genetically engineered to synthesize and assemble hepatitis B surface antigen particles containing 55 additional amino acids encoded by the hepatitis B virus preS gene. These particles are composed of a 28,000 dalton protein and efficiently bind polymerized human albumin. Antibodies to the polyalbumin receptor epitope of this particle may interfere with the postulated polyalbumin-mediated binding of HBV to hepatocytes and may therefore be particularly efficient in preventing the disease.",

author = "Pablo Valenzuela and Doris Coit and Kuo, \{Ching H.\}",

year = "1985",

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doi = "10.1038/nbt0485-317",

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AU - Valenzuela, Pablo

AU - Coit, Doris

AU - Kuo, Ching H.

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Y1 - 1985/1/1

N2 - Yeast cells are genetically engineered to synthesize and assemble hepatitis B surface antigen particles containing 55 additional amino acids encoded by the hepatitis B virus preS gene. These particles are composed of a 28,000 dalton protein and efficiently bind polymerized human albumin. Antibodies to the polyalbumin receptor epitope of this particle may interfere with the postulated polyalbumin-mediated binding of HBV to hepatocytes and may therefore be particularly efficient in preventing the disease.

AB - Yeast cells are genetically engineered to synthesize and assemble hepatitis B surface antigen particles containing 55 additional amino acids encoded by the hepatitis B virus preS gene. These particles are composed of a 28,000 dalton protein and efficiently bind polymerized human albumin. Antibodies to the polyalbumin receptor epitope of this particle may interfere with the postulated polyalbumin-mediated binding of HBV to hepatocytes and may therefore be particularly efficient in preventing the disease.

UR - https://www.scopus.com/pages/publications/0021827684

U2 - 10.1038/nbt0485-317

DO - 10.1038/nbt0485-317

M3 - Letter

AN - SCOPUS:0021827684

SN - 0733-222X

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Synthesis and assembly in yeast of hepatitis b surface antigen particles containing the polyalbumin receptor

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