Synthesis and assembly in yeast of hepatitis b surface antigen particles containing the polyalbumin receptor

Pablo Valenzuela, Doris Coit, Ching H. Kuo

Resultado de la investigación: Letter

37 Citas (Scopus)

Resumen

Yeast cells are genetically engineered to synthesize and assemble hepatitis B surface antigen particles containing 55 additional amino acids encoded by the hepatitis B virus preS gene. These particles are composed of a 28,000 dalton protein and efficiently bind polymerized human albumin. Antibodies to the polyalbumin receptor epitope of this particle may interfere with the postulated polyalbumin-mediated binding of HBV to hepatocytes and may therefore be particularly efficient in preventing the disease.

Idioma originalEnglish
Páginas (desde-hasta)317-320
Número de páginas4
PublicaciónBio/Technology
Volumen3
N.º4
DOI
EstadoPublished - 1 ene 1985

Huella dactilar

Epitopes
Surface Antigens
Antigens
Viruses
Antibodies
Yeast
Hepatitis
Amino acids
Genes
Yeasts
Cells
Proteins
Hepatitis B Surface Antigens
Hepatitis B virus
Hepatocytes
Amino Acids
polyalbumin

ASJC Scopus subject areas

  • Biotechnology

Citar esto

Valenzuela, Pablo ; Coit, Doris ; Kuo, Ching H. / Synthesis and assembly in yeast of hepatitis b surface antigen particles containing the polyalbumin receptor. En: Bio/Technology. 1985 ; Vol. 3, N.º 4. pp. 317-320.
@article{d05948e82061482786303fe04b7ab196,
title = "Synthesis and assembly in yeast of hepatitis b surface antigen particles containing the polyalbumin receptor",
abstract = "Yeast cells are genetically engineered to synthesize and assemble hepatitis B surface antigen particles containing 55 additional amino acids encoded by the hepatitis B virus preS gene. These particles are composed of a 28,000 dalton protein and efficiently bind polymerized human albumin. Antibodies to the polyalbumin receptor epitope of this particle may interfere with the postulated polyalbumin-mediated binding of HBV to hepatocytes and may therefore be particularly efficient in preventing the disease.",
author = "Pablo Valenzuela and Doris Coit and Kuo, {Ching H.}",
year = "1985",
month = "1",
day = "1",
doi = "10.1038/nbt0485-317",
language = "English",
volume = "3",
pages = "317--320",
journal = "Nature Biotechnology",
issn = "1087-0156",
publisher = "Nature Publishing Group",
number = "4",

}

Synthesis and assembly in yeast of hepatitis b surface antigen particles containing the polyalbumin receptor. / Valenzuela, Pablo; Coit, Doris; Kuo, Ching H.

En: Bio/Technology, Vol. 3, N.º 4, 01.01.1985, p. 317-320.

Resultado de la investigación: Letter

TY - JOUR

T1 - Synthesis and assembly in yeast of hepatitis b surface antigen particles containing the polyalbumin receptor

AU - Valenzuela, Pablo

AU - Coit, Doris

AU - Kuo, Ching H.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Yeast cells are genetically engineered to synthesize and assemble hepatitis B surface antigen particles containing 55 additional amino acids encoded by the hepatitis B virus preS gene. These particles are composed of a 28,000 dalton protein and efficiently bind polymerized human albumin. Antibodies to the polyalbumin receptor epitope of this particle may interfere with the postulated polyalbumin-mediated binding of HBV to hepatocytes and may therefore be particularly efficient in preventing the disease.

AB - Yeast cells are genetically engineered to synthesize and assemble hepatitis B surface antigen particles containing 55 additional amino acids encoded by the hepatitis B virus preS gene. These particles are composed of a 28,000 dalton protein and efficiently bind polymerized human albumin. Antibodies to the polyalbumin receptor epitope of this particle may interfere with the postulated polyalbumin-mediated binding of HBV to hepatocytes and may therefore be particularly efficient in preventing the disease.

UR - http://www.scopus.com/inward/record.url?scp=0021827684&partnerID=8YFLogxK

U2 - 10.1038/nbt0485-317

DO - 10.1038/nbt0485-317

M3 - Letter

VL - 3

SP - 317

EP - 320

JO - Nature Biotechnology

JF - Nature Biotechnology

SN - 1087-0156

IS - 4

ER -