Synthesis and assembly in yeast of hepatitis b surface antigen particles containing the polyalbumin receptor

Pablo Valenzuela; Doris Coit; Ching H. Kuo

doi:10.1038/nbt0485-317

Synthesis and assembly in yeast of hepatitis b surface antigen particles containing the polyalbumin receptor

Pablo Valenzuela, Doris Coit, Ching H. Kuo

Facultad de Ciencias de la Vida

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38 Citas (Scopus)

Resumen

Yeast cells are genetically engineered to synthesize and assemble hepatitis B surface antigen particles containing 55 additional amino acids encoded by the hepatitis B virus preS gene. These particles are composed of a 28,000 dalton protein and efficiently bind polymerized human albumin. Antibodies to the polyalbumin receptor epitope of this particle may interfere with the postulated polyalbumin-mediated binding of HBV to hepatocytes and may therefore be particularly efficient in preventing the disease.

Idioma original	Inglés
Páginas (desde-hasta)	317-320
Número de páginas	4
Publicación	Bio/Technology
Volumen	3
N.º	4
DOI	https://doi.org/10.1038/nbt0485-317
Estado	Publicada - 1 ene. 1985

Áreas temáticas de ASJC Scopus

Biotecnología

ODS de las Naciones Unidas

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10.1038/nbt0485-317

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abstract = "Yeast cells are genetically engineered to synthesize and assemble hepatitis B surface antigen particles containing 55 additional amino acids encoded by the hepatitis B virus preS gene. These particles are composed of a 28,000 dalton protein and efficiently bind polymerized human albumin. Antibodies to the polyalbumin receptor epitope of this particle may interfere with the postulated polyalbumin-mediated binding of HBV to hepatocytes and may therefore be particularly efficient in preventing the disease.",

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AB - Yeast cells are genetically engineered to synthesize and assemble hepatitis B surface antigen particles containing 55 additional amino acids encoded by the hepatitis B virus preS gene. These particles are composed of a 28,000 dalton protein and efficiently bind polymerized human albumin. Antibodies to the polyalbumin receptor epitope of this particle may interfere with the postulated polyalbumin-mediated binding of HBV to hepatocytes and may therefore be particularly efficient in preventing the disease.

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Synthesis and assembly in yeast of hepatitis b surface antigen particles containing the polyalbumin receptor

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