Synthesis and assembly in yeast of hepatitis b surface antigen particles containing the polyalbumin receptor

Pablo Valenzuela, Doris Coit, Ching H. Kuo

Resultado de la investigación: Contribución a una revistaCarta

37 Citas (Scopus)

Resumen

Yeast cells are genetically engineered to synthesize and assemble hepatitis B surface antigen particles containing 55 additional amino acids encoded by the hepatitis B virus preS gene. These particles are composed of a 28,000 dalton protein and efficiently bind polymerized human albumin. Antibodies to the polyalbumin receptor epitope of this particle may interfere with the postulated polyalbumin-mediated binding of HBV to hepatocytes and may therefore be particularly efficient in preventing the disease.

Idioma originalInglés
Páginas (desde-hasta)317-320
Número de páginas4
PublicaciónBio/Technology
Volumen3
N.º4
DOI
EstadoPublicada - 1 ene 1985

Áreas temáticas de ASJC Scopus

  • Biotecnología

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